Łagiewka Jakub, Girek Tomasz, Ciesielski Wojciech
Faculty of Mathematics and Natural Science, Jan Dlugosz University in Czestochowa, Armii Krajowej Ave., 13/15, 42 201 Czestochowa, Poland.
Polymers (Basel). 2021 May 27;13(11):1759. doi: 10.3390/polym13111759.
Cyclodextrins (CDs) are a family of macrocyclic oligosaccharides mostly composed of six, seven, or eight α-D-glucopyranose units with α-1,4-glycosidic bonds to form toroidal structures. The CDs possess a hydrophilic exterior and hydrophobic interior with the ability to form an inclusion complex, especially with hydrophobic molecules. However, most existing studies are about conjugation CDs with peptide/protein focusing on the formation of new systems. The CD-peptide/protein can possess new abilities; particularly, the cavity can be applied in modulation properties of more complexed proteins. Most studies are focused on drug delivery, such as targeted delivery in cell-penetrating peptides or co-delivery. The co-delivery is based mostly on polylysine systems; on the other hand, the CD-peptide allows us to understand biomolecular mechanisms such as fibryllation or stem cell behaviour. Moreover, the CD-proteins are more complexed systems with a focus on targeted therapy; these conjugates might be controllable with various properties due to changes in their stability. Finally, the studies of CD-peptide/protein are promising in biomedical application and provide new possibilities for the conjugation of simple molecules to biomolecules.
环糊精（CDs）是一类大环寡糖，主要由六个、七个或八个α-D-吡喃葡萄糖单元组成，通过α-1,4-糖苷键形成环形结构。环糊精具有亲水性的外部和疏水性的内部，能够形成包合物，特别是与疏水分子形成包合物。然而，大多数现有研究是关于环糊精与肽/蛋白质的缀合，重点在于新体系的形成。环糊精-肽/蛋白质可以具有新的能力；特别是，其空腔可用于调节更复杂蛋白质的性质。大多数研究集中在药物递送方面，例如在细胞穿透肽中的靶向递送或共递送。共递送主要基于聚赖氨酸体系；另一方面，环糊精-肽使我们能够理解诸如纤维化或干细胞行为等生物分子机制。此外，环糊精-蛋白质是更复杂的体系，重点在于靶向治疗；由于其稳定性的变化，这些缀合物可能具有各种可控的性质。最后，环糊精-肽/蛋白质的研究在生物医学应用中具有前景，并为简单分子与生物分子的缀合提供了新的可能性。
