Brachtel D, Richter E
Medizinische Abteilung Krankenanstalt Mutterhaus der Borromäerinen Trier.
Z Gastroenterol. 1988 May;26(5):245-51.
The effect of altered gastric emptying on caffeine absorption (tablets; 366.1 mg) was studied in patients with gastric stasis or after Billroth II partial gastrectomy with adequate gastric emptying and in healthy subjects with slowed gastric emptying due to a fibre-free and a fibre-rich liquid test meal of an elemental diet, respectively. Compared with controls (n = 15), a significantly slowed caffeine absorption was found in gastric stasis (n = 8) by means of a lower absorption rate constant KA (0.018 +/- 0.007 vs. 0.122 +/- 0.110 min-1 in controls) and a prolonged peak time tmax (160 +/- 77 vs. 46 +/- 19 min). Similar results were obtained after a fibre-free and a fibre-rich liquid test meal, respectively (n = 8 and n = 8, respectively; KA 0.035 +/- 0.01 and 0.035 +/- 0.023 min-1, respectively; tmax 91 +/- 24 and 93 +/- 23 min, respectively vs. KA 0.10 +/- 0.06 min-1 and tmax 50 +/- 14 min in controls; n = 7). After B II with adequate gastric emptying (n = 11) the absorption rate was within the normal range. The significantly lower average of the peak concentration cmax and of the area under the serum concentration-time curve x elimination rate constant (AUC x KE) in gastric stasis (5.9 +/- 1.8 micrograms/ml and 8.9 +/- 3.2 mg/l, respectively) and after B II partial gastrectomy (8.8 +/- 2.6 micrograms/ml and 10.8 +/- 3.0 mg/l, respectively) compared with controls (17.7 +/- 9.4 micrograms/ml and 20.8 +/- 10.7 mg/l respectively) probably reflect reduced bioavailability, which is apparently unchanged after a liquid test meal.
研究了胃排空改变对咖啡因吸收（片剂；366.1毫克）的影响，研究对象分别为患有胃潴留的患者、胃排空正常的毕罗Ⅱ式胃部分切除术后患者，以及因无纤维和富含纤维的要素饮食液体试验餐导致胃排空减慢的健康受试者。与对照组（n = 15）相比，胃潴留组（n = 8）咖啡因吸收显著减慢，表现为吸收速率常数KA较低（对照组为0.122±0.110分钟⁻¹，胃潴留组为0.018±0.007分钟⁻¹）以及达峰时间tmax延长（对照组为46±19分钟，胃潴留组为160±77分钟）。分别给予无纤维和富含纤维的液体试验餐后也得到了类似结果（分别为n = 8和n = 8；KA分别为0.035±0.01和0.035±0.023分钟⁻¹；tmax分别为91±24和93±23分钟，而对照组KA为0.10±0.06分钟⁻¹，tmax为50±14分钟；n = 7）。胃排空正常的毕罗Ⅱ式胃部分切除术后组（n = 11）吸收速率在正常范围内。与对照组（分别为17.7±9.4微克/毫升和20.8±10.7毫克/升）相比，胃潴留组（分别为5.9±1.8微克/毫升和8.9±3.2毫克/升）以及毕罗Ⅱ式胃部分切除术后组（分别为8.8±2.6微克/毫升和10.8±3.0毫克/升）的峰浓度cmax平均值和血清浓度-时间曲线下面积x消除速率常数（AUCxKE）显著较低，这可能反映了生物利用度降低，而液体试验餐后生物利用度显然未改变。
