脑胶质瘤（GBM）中线粒体 DNA 改变。
Mitochondrial DNA Alterations in Glioblastoma (GBM).
机构信息
Molecular Biology Laboratory, Biological Sciences Institute, Federal University of Para, Belém, PA 66075, Brazil.
Paragominas Campus, Federal Rural University of Amazonia, Paragominas, PA 68627, Brazil.
出版信息
Int J Mol Sci. 2021 May 29;22(11):5855. doi: 10.3390/ijms22115855.
Abstract
Glioblastoma (GBM) is an extremely aggressive tumor originating from neural stem cells of the central nervous system, which has high histopathological and genomic diversity. Mitochondria are cellular organelles associated with the regulation of cellular metabolism, redox signaling, energy generation, regulation of cell proliferation, and apoptosis. Accumulation of mutations in mitochondrial DNA (mtDNA) leads to mitochondrial dysfunction that plays an important role in GBM pathogenesis, favoring abnormal energy and reactive oxygen species production and resistance to apoptosis and to chemotherapeutic agents. The present review summarizes the known mitochondrial DNA alterations related to GBM, their cellular and metabolic consequences, and their association with diagnosis, prognosis, and treatment.
摘要
胶质母细胞瘤（GBM）是一种源自中枢神经系统神经干细胞的极具侵袭性肿瘤，具有高度的组织病理学和基因组多样性。线粒体是与细胞代谢、氧化还原信号、能量产生、细胞增殖和细胞凋亡调节相关的细胞细胞器。线粒体 DNA（mtDNA）突变的积累导致线粒体功能障碍，在 GBM 发病机制中发挥重要作用，促进异常能量和活性氧的产生，并对细胞凋亡和化疗药物产生抵抗。本综述总结了已知与 GBM 相关的线粒体 DNA 改变、它们的细胞和代谢后果，以及它们与诊断、预后和治疗的关联。
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