Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900, USA.
Cells. 2021 May 26;10(6):1324. doi: 10.3390/cells10061324.
Arboviruses are known to cause large-scale epidemics in many parts of the world. These arthropod-borne viruses are a large group consisting of viruses from a wide range of families. The ability of their vector to enhance viral pathogenesis and transmission makes the development of treatments against these viruses challenging. Neutrophils are generally the first leukocytes to be recruited to a site of infection, playing a major role in regulating inflammation and, as a result, viral replication and dissemination. However, the underlying mechanisms through which neutrophils control the progression of inflammation and disease remain to be fully understood. In this review, we highlight the major findings from recent years regarding the role of neutrophils during arboviral infections. We discuss the complex nature of neutrophils in mediating not only protection, but also augmenting disease pathology. Better understanding of neutrophil pathways involved in effective protection against arboviral infections can help identify potential targets for therapeutics.
虫媒病毒在世界许多地区已知会引起大规模的流行。这些节肢动物传播的病毒是一个由广泛家族的病毒组成的大群组。其载体增强病毒发病机制和传播的能力使得针对这些病毒的治疗方法的开发具有挑战性。中性粒细胞通常是被招募到感染部位的第一批白细胞，在调节炎症中起着重要作用，因此，病毒的复制和传播。然而，中性粒细胞控制炎症和疾病进展的潜在机制仍有待充分理解。在这篇综述中，我们强调了近年来关于中性粒细胞在虫媒病毒感染中的作用的主要发现。我们讨论了中性粒细胞在介导不仅保护，而且增强疾病病理的复杂性质。更好地了解中性粒细胞在有效对抗虫媒病毒感染中的作用途径可以帮助确定潜在的治疗靶点。
