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PLoS Negl Trop Dis. 2018 Jul 18;12(7):e0006626. doi: 10.1371/journal.pntd.0006626. eCollection 2018 Jul.
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The Discovery of Arthropod-Specific Viruses in Hematophagous Arthropods: An Open Door to Understanding the Mechanisms of Arbovirus and Arthropod Evolution?在吸血节肢动物中发现节肢动物特异性病毒：打开了解虫媒病毒和节肢动物进化机制的大门？
Annu Rev Entomol. 2018 Jan 7;63:87-103. doi: 10.1146/annurev-ento-020117-043033.
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Temperature Increase Enhances Competence to Transmit Dengue Virus.温度升高增强登革病毒传播能力。
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Am J Trop Med Hyg. 2017 Jan 11;96(1):148-156. doi: 10.4269/ajtmh.16-0516. Epub 2016 Dec 5.
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虫媒病毒-蚊媒-宿主相互作用及其对虫媒病毒传播和疾病发病机制的影响。

Arbovirus-Mosquito Vector-Host Interactions and the Impact on Transmission and Disease Pathogenesis of Arboviruses.

作者信息

Huang Yan-Jang S, Higgs Stephen, Vanlandingham Dana L

机构信息

Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States.

Biosecurity Research Institute, Kansas State University, Manhattan, KS, United States.

出版信息

Front Microbiol. 2019 Jan 23;10:22. doi: 10.3389/fmicb.2019.00022. eCollection 2019.

DOI:10.3389/fmicb.2019.00022
PMID:30728812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6351451/
Abstract

Hundreds of viruses, designated as arboviruses, are transmitted by arthropod vectors in complex transmission cycles between the virus, vertebrate host, and the vector. With millions of human and animal infections per year, it is critical to improve our understanding of the interactions between the biological and environmental factors that play a critical role in pathogenesis, disease outcomes, and transmission of arboviruses. This review focuses on mosquito-borne arboviruses and discusses current knowledge of the factors and underlying mechanisms that influence infection and transmission of arboviruses and discusses critical factors and pathways that can potentially become targets for intervention and therapeutics.

摘要

数百种被称为虫媒病毒的病毒，通过节肢动物媒介在病毒、脊椎动物宿主和媒介之间复杂的传播循环中进行传播。每年有数以百万计的人类和动物感染病例，因此加深我们对在虫媒病毒发病机制、疾病转归及传播过程中起关键作用的生物和环境因素之间相互作用的理解至关重要。本综述聚焦于蚊媒传播的虫媒病毒，讨论了影响虫媒病毒感染和传播的因素及潜在机制的现有知识，并探讨了可能成为干预和治疗靶点的关键因素及途径。