Department of Agricultural and Food Sciences, Alma Mater Studiorum-University di Bologna, 40127 Bologna, Italy.
Int J Mol Sci. 2021 May 24;22(11):5514. doi: 10.3390/ijms22115514.
Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. This review will provide an overview of the information regarding 10 dietarypolyphenols (ferulic acid, chlorogenic acid, rutin, quercetin, apigenin, cirsimaritin, daidzein, resveratrol, ellagic acid, and curcumin) and their association with the BCS classification.
多酚是植物产生的天然有机化合物，通过与 ROS 反应充当抗氧化剂。这些化合物在日常饮食中广泛摄入，许多研究报告称，由于它们在人类体内的生物利用度，对人类健康有多种益处。然而，酚类化合物的消化过程仍不完全清楚。此外，生物利用度取决于这些化合物的代谢阶段。LogP 值可以作为一种简单的方法来衡量人体摄入物质的亲脂性，这会影响到吸收效果。生物药剂学分类系统 (BCS) 是一种用于分类胃肠道吸收药物的方法，它将药物的溶解度和渗透性与口服吸收的速度和程度相关联。BCS 可能有助于测量食品中的生物活性成分，如多酚，以了解它们的营养潜力。有许多文献研究集中在多酚及其代谢产物的通透性、吸收和生物利用度上，但它们各自的 LogP 值和 BCS 分类仍然存在混淆。本文综述了 10 种膳食多酚（阿魏酸、绿原酸、芦丁、槲皮素、芹菜素、白藜芦醇、大豆苷元、白藜芦醇、鞣花酸和姜黄素）及其与 BCS 分类的关系的信息。
