Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, P.R. China.
Food Funct. 2021 Jul 21;12(14):6442-6451. doi: 10.1039/d1fo00825k. Epub 2021 Jun 1.
Currently, little is known regarding the association between dietary choline intake and osteoporosis in elderly individuals, as well as if such intakes affect bone health and result in fractures. This study was aimed to examine associations between daily dietary choline intake and osteoporosis in elderly individuals. A total of 31 034 participants from the National Health and Nutritional Examination Survey (NHANES) during 2005-2010 were enrolled, and 3179 participants with complete data and aged 65 years and older were identified. Baseline characteristics and dietary intake data were obtained through method of in-home administered questionnaires. Of 3179 individuals with a mean age of 73.7 ± 5.6 years, female (P < 0.001) and non-hispanic white (P < 0.001) occupied a higher proportion in the osteoporosis group. The logistic regression analysis indicated that the prevalence of osteoporosis in three tertile categories with gradually enhanced dietary choline intake was decreased progressively (P for trend <0.001). The restricted cubic spline (RCS) showed that the risk of osteoporosis generally decreased with increasing daily dietary choline intake (P < 0.001), while this trend was not apparent in relation between the daily dietary choline intake and risk of hip fracture (P = 0.592). The receiver operating characteristic (ROC) analysis identified a daily dietary choline intake of 232.1 mg as the optimal cutoff value for predicting osteoporosis. Our nationwide data suggested that a lower level of daily dietary choline intake was positively associated with the increased risk of osteoporosis in the US elderly population.
目前，人们对于老年人饮食胆碱摄入量与骨质疏松症之间的关系知之甚少，也不清楚这种摄入量是否会影响骨骼健康并导致骨折。本研究旨在探讨老年人日常饮食胆碱摄入量与骨质疏松症之间的关系。我们共纳入了 2005-2010 年国家健康和营养调查（NHANES）中的 31034 名参与者，确定了 3179 名数据完整且年龄在 65 岁及以上的参与者。通过入户问卷调查的方式获得了参与者的基线特征和饮食摄入数据。在 3179 名平均年龄为 73.7±5.6 岁的参与者中，骨质疏松症组中女性（P<0.001）和非西班牙裔白人（P<0.001）的比例较高。逻辑回归分析表明，随着饮食胆碱摄入量逐渐增加的三个三分位组中，骨质疏松症的患病率逐渐降低（趋势 P<0.001）。受限立方样条（RCS）显示，骨质疏松症的风险通常随着每日饮食胆碱摄入量的增加而降低（P<0.001），而这种趋势与每日饮食胆碱摄入量与髋部骨折风险之间没有明显的关联（P=0.592）。受试者工作特征（ROC）分析确定 232.1mg/d 的每日饮食胆碱摄入量为预测骨质疏松症的最佳截断值。我们的全国性数据表明，美国老年人每日饮食胆碱摄入量较低与骨质疏松症风险增加呈正相关。
