Haddow J E, Knight G J, Palomaki G E, McCarthy J E
Foundation for Blood Research, Scarborough, ME 04074.
Am J Obstet Gynecol. 1988 Aug;159(2):481-4. doi: 10.1016/s0002-9378(88)80114-5.
In this study the relationship between birth weight and passive exposure to tobacco smoke is assessed for the first time by serum cotinine measurements. Among 1231 nonsmoking white women whose blood was sampled during the second trimester of pregnancy, 31.4% had serum cotinine levels between 1.0 and 9.9 ng/ml and were therefore considered to be passively exposed to tobacco smoke. The crude mean birth weight of infants of the women passively exposed to smoke was 107 gm lower than that of infants of unexposed women, and that difference remained after the application of a multivariate analysis that included the major known birth weight-associated covariates. These findings are consistent with a causal relationship between passive exposure to tobacco smoke and birth weight and suggest that the dose-response relationship may not be linear.
在本研究中，首次通过血清可替宁测量评估出生体重与被动接触烟草烟雾之间的关系。在1231名怀孕中期采血的非吸烟白人女性中，31.4%的血清可替宁水平在1.0至9.9纳克/毫升之间，因此被认为是被动接触了烟草烟雾。被动接触烟雾的女性所生婴儿的粗平均出生体重比未接触女性所生婴儿低107克，在纳入主要已知的与出生体重相关的协变量进行多变量分析后，这种差异仍然存在。这些发现与被动接触烟草烟雾和出生体重之间的因果关系一致，并表明剂量反应关系可能不是线性的。
