State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Brain Res Bull. 2021 Sep;174:268-280. doi: 10.1016/j.brainresbull.2021.05.024. Epub 2021 May 30.
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders and the main symptoms of ASD are impairments in social communication and abnormal behavioral patterns. Studies have shown that immune dysfunction and neuroinflammation play a key role in ASD patients and experimental models. Chemokines are groups of small proteins that regulate cell migration and mediate inflammation responses via binding to chemokine receptors. Thus, chemokines/chemokine receptors may be involved in neurodevelopmental disorders and associated with ASD. In this review, we summarize the research progress of chemokine aberrations in ASD and also review the recent progress of clinical treatment of ASD and pharmacological research related to chemokines/chemokine receptors. This review highlights the possible connection between chemokines/chemokine receptors and ASD, and provides novel potential targets for drug discovery of ASD.
自闭症谱系障碍（ASD）是一组神经发育障碍，ASD 的主要症状是社交沟通障碍和异常行为模式。研究表明，免疫功能障碍和神经炎症在 ASD 患者和实验模型中起着关键作用。趋化因子是一组调节细胞迁移并通过与趋化因子受体结合来介导炎症反应的小蛋白。因此，趋化因子/趋化因子受体可能参与神经发育障碍，并与 ASD 相关。在这篇综述中，我们总结了 ASD 中趋化因子异常的研究进展，同时也回顾了 ASD 的临床治疗和与趋化因子/趋化因子受体相关的药理学研究的最新进展。本综述强调了趋化因子/趋化因子受体与 ASD 之间可能存在的联系，并为 ASD 的药物发现提供了新的潜在靶点。
