Miniati M, Parker J C, Pistolesi M, Cartledge J T, Martin D J, Giuntini C, Taylor A E
National Research Council Institute of Clinical Physiology, University of Pisa, Italy.
Am J Physiol. 1988 Aug;255(2 Pt 2):H375-85. doi: 10.1152/ajpheart.1988.255.2.H375.
The reabsorption of albumin from the pleural space was measured in eight dogs receiving 0.5 ml intrapleural injection of 131I-labeled albumin and a simultaneous intravenous injection of 125I-labeled albumin. Plasma curves for both tracers were obtained over 24 h. The 125I-albumin curve served as input function of albumin for interstitial spaces, including pleura, whereas the 131I-albumin curve represented the output function from pleural space. The frequency function of albumin transit times from pleural space to plasma was obtained by deconvolution of input-output plasma curves. Plasma recovery of 131I-albumin was complete by 24 h, and the mean transit time from pleura to plasma averaged 7.95 +/- 1.57 (SD) h. Albumin reabsorption occurred mainly via lymphatics as indicated by experiments in 16 additional dogs in which their right lymph ducts or thoracic ducts were ligated before intrapleural injection. A pleural lymph flow of 0.020 +/- 0.003 (SD) ml.kg-1.h-1 was estimated, which is balanced by a comparable filtration of fluid into the pleural space. This suggests that, under physiological conditions, the subpleural lymphatics represent an important control mechanism of pleural liquid pressure.
在八只狗身上测量了胸膜腔内白蛋白的重吸收情况，这些狗接受了0.5毫升胸膜腔内注射的131I标记白蛋白，并同时静脉注射了125I标记白蛋白。在24小时内获得了两种示踪剂的血浆曲线。125I-白蛋白曲线作为包括胸膜在内的间质空间白蛋白的输入函数，而131I-白蛋白曲线代表胸膜腔的输出函数。通过对输入-输出血浆曲线进行去卷积获得白蛋白从胸膜腔到血浆的转运时间频率函数。131I-白蛋白在24小时时血浆回收率达到100%，从胸膜到血浆的平均转运时间平均为7.95±1.57（标准差）小时。另外16只狗的实验表明，白蛋白重吸收主要通过淋巴管进行，在这些狗中，它们的右淋巴管或胸导管在胸膜腔内注射前被结扎。估计胸膜淋巴流量为0.020±0.003（标准差）毫升·千克-1·小时-1，这与液体向胸膜腔的类似滤过相平衡。这表明，在生理条件下，胸膜下淋巴管代表了胸膜液压力的重要控制机制。
