School of Medicine, Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Rev Med Virol. 2022 Jan;32(1):e2262. doi: 10.1002/rmv.2262. Epub 2021 Jun 2.
Coronavirus disease (Covid-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently the largest health crisis facing most countries. Several factors have been linked with a poor prognosis for this disease, including demographic factors, pre-existing comorbidities and laboratory parameters such as white blood cell count, D-dimer, C-reactive protein, albumin, lactate dehydrogenase, creatinine and electrolytes. Electrolyte abnormalities particularly potassium disorders are common among Covid-19 patients. Based on our pooled analysis, hypokalemia and hyperkalemia occur in 24.3% and 4.15% of Covid-19 patients, respectively. Potassium level deviation from the normal range may increase the chances of unfavorable outcomes and even death. Therefore, this article reviewed the epidemiology of potassium disorders and explained how hypokalemia and hyperkalemia are capable of deteriorating cardiac outcomes and the prognosis of Covid-19 for infected patients. The article finishes by highlighting some important considerations in the management of hypokalemia and hyperkalemia in these patients.
冠状病毒病（COVID-19）由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起，是目前大多数国家面临的最大健康危机。一些因素与该疾病的预后不良有关，包括人口统计学因素、先前存在的合并症和实验室参数，如白细胞计数、D-二聚体、C 反应蛋白、白蛋白、乳酸脱氢酶、肌酐和电解质。电解质异常，特别是钾紊乱，在 COVID-19 患者中很常见。根据我们的汇总分析，低钾血症和高钾血症分别发生在 24.3%和 4.15%的 COVID-19 患者中。钾水平偏离正常范围可能会增加不良结局甚至死亡的机会。因此，本文综述了钾紊乱的流行病学，并解释了低钾血症和高钾血症如何使感染患者的心脏结局和 COVID-19 预后恶化。文章最后强调了在这些患者低钾血症和高钾血症管理中的一些重要注意事项。
