From the Biochemistry Department (Nasif, Alamodi, Alrefai); from the Pathology Department (Ali); and from College of Medicine (Alzubedi, Almasoudi, Sulaimani, Sulaiman, Alharbi), Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
Saudi Med J. 2021 Jun;42(6):643-648. doi: 10.15537/smj.2021.42.6.20210103.
To investigate prevalence and association between iron deficiency anemia (IDA) and ).
This cross-sectional study included 79 participants with unexplained IDA. The study was carried out between November 2018 to April 2020 in the College of Medicine, Umm Al-Qura University in collaboration with Al-Noor Specialist Hospital, Makkah, Saudi Arabia. Complete blood count (CBC), serum iron, and ferritin levels were measured. Anti- antibody was detected using anti- immunoglobulin G enzyme-linked immunosorbent assay (ELISA).
The prevalence of infection among IDA patients was 62%. There was a significant difference between female and male subjects with a positive status (=0.001). There was also a significant difference between females and males with a positive infection according to red blood cell count, hematocrit, mean corpuscular volume, and mean cor-puscular hemoglobin (=0.001).
The current study shows an association between infection and unexplained IDA with significant difference between postmenopausal Saudi females and males. This will lead to more effective treatment in IDA and the eradication of , as well as the prevention of recurrence, which are necessary and may provide a significant reduction in the overall disease burden.
调查缺铁性贫血（IDA）与 ）之间的患病率和关联。
本横断面研究纳入了 79 例原因不明的 IDA 患者。该研究于 2018 年 11 月至 2020 年 4 月在沙特阿拉伯麦加的 Umm Al-Qura 大学医学院与 Al-Noor 专科医院合作进行。测量了全血细胞计数（CBC）、血清铁和铁蛋白水平。使用抗免疫球蛋白 G 酶联免疫吸附试验（ELISA）检测 抗体。
IDA 患者中 的感染率为 62%。阳性 状态的女性和男性之间存在显著差异（=0.001）。根据红细胞计数、血细胞比容、平均红细胞体积和平均红细胞血红蛋白，女性和男性中阳性 感染之间也存在显著差异（=0.001）。
本研究显示 感染与不明原因 IDA 之间存在关联，绝经后沙特女性和男性之间存在显著差异。这将导致 IDA 的治疗更加有效，并根除 ，以及预防复发，这是必要的，可能会显著降低整体疾病负担。
