Bianco Blandine, François-Garret Bérengère, Butin Marine, Dalmasso Cyril, Casagrande Florence, Mokhtari Mostafa, Eleni Dit Trolli Sergio
Neonatal Intensive Care Unit, CHU de Nice, Archet 2 Hospital, Nice, France.
Neonatal Intensive Care Unit, Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Bron, France.
Front Pediatr. 2021 May 17;9:623043. doi: 10.3389/fped.2021.623043. eCollection 2021.
To evaluate the positive threshold of PCT for neonates of <32 weeks of gestation for the diagnosis of early-onset sepsis and to determine if the level of PCT collected within 6 h of life could be used. Retrospective and bicentric study from May 2016 to April 2018. Two groups were established, neonates evaluated for PCT at birth (CordPCT) and within 6 h of life (delPCT). Two hundred and sixty neonates of <32 weeks of gestation born in Nice and South Paris (Bicêtre) University Hospitals, had been evaluated for PCT level. The value of the PCT positive threshold was determined for the total population and each groups thanks ROC curves. The threshold level of PCT for the total population was 0.98 ng/mL. The threshold value of cordPCT group was 1.00 vs. 0.98 ng/mL for delPCT group. The area under the Receiver Operating Characteristics curve for PCT sampled in delPCT group was significantly higher than in cordPCT group (0.94 compared to 0.75). The threshold level of PCT was higher in this cohort of neonates of <32 weeks of gestation compared to the value generally described for term neonates. The secondary sampling PCT level seems to be usable in screening algorithm for early-onset neonatal sepsis.
评估胎龄<32周的新生儿用于早发型败血症诊断的降钙素原（PCT）阳性阈值，并确定出生后6小时内采集的PCT水平是否可用。2016年5月至2018年4月的回顾性双中心研究。设立了两组，即出生时评估PCT的新生儿（脐血PCT）和出生后6小时内评估PCT的新生儿（延迟PCT）。对在尼斯和巴黎南部（比塞特尔）大学医院出生的260例胎龄<32周的新生儿进行了PCT水平评估。通过ROC曲线确定了总人群和每组的PCT阳性阈值。总人群的PCT阈值水平为0.98 ng/mL。脐血PCT组的阈值为1.00 ng/mL，而延迟PCT组为0.98 ng/mL。延迟PCT组采样的PCT的受试者操作特征曲线下面积显著高于脐血PCT组（分别为0.94和0.75）。与足月新生儿通常描述的值相比，该组胎龄<32周的新生儿的PCT阈值水平更高。二次采样PCT水平似乎可用于早发型新生儿败血症的筛查算法。
