胃癌相关基因多态性与胃癌风险的关联：一项病例对照研究。
Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study.
作者信息
Pu Yan, Wen Xu, Jia Zhangjun, Xie Yu, Luan Changxing, Yu Youjia, Chen Feng, Chen Peng, Li Ding, Sun Yan, Zhao Jian, Lv Haiqin
机构信息
School of Medicine, Southeast University, Nanjing, China.
Department of General Surgery, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
出版信息
Front Mol Biosci. 2021 May 17;8:690665. doi: 10.3389/fmolb.2021.690665. eCollection 2021.
Gastric cancer has the second highest incidence among all the malignancies in China, just below lung cancer. Gastric cancer is likewise one of the main sources of cancer related passings. Gastric cancer therefore remains a huge threat to human health. The primary reason is absence of high sensitivity and specificity for early detection while the pathogenesis of GC is stayed muddled. During the last few decades, a lot of GC related genes have been identified. To find candidate GC related variant in these GC related genes, we conducted this case-control study. 29 tagSNPs located in 7 GC related genes were included. 228 gastric cancer patients and 299 healthy controls were enrolled. Significant differences were found between the genotype frequencies of rs4971066 polymorphism between gastric cancer patients and healthy controls. The result indicated that ephrin-A1 tagSNP rs4971066 GT/TT genotypes was significantly associated with reduced susceptibility of gastric cancer development.
在中国，胃癌的发病率在所有恶性肿瘤中位居第二，仅次于肺癌。胃癌同样也是癌症相关死亡的主要原因之一。因此，胃癌仍然对人类健康构成巨大威胁。主要原因是早期检测缺乏高灵敏度和特异性，同时胃癌的发病机制仍不清楚。在过去几十年里，已经鉴定出许多与胃癌相关的基因。为了在这些与胃癌相关的基因中寻找候选的胃癌相关变异，我们进行了这项病例对照研究。研究纳入了位于7个与胃癌相关基因中的29个标签单核苷酸多态性（tagSNP）。招募了228例胃癌患者和299例健康对照。在胃癌患者和健康对照之间，rs4971066多态性的基因型频率存在显著差异。结果表明，ephrin-A1标签单核苷酸多态性rs4971066的GT/TT基因型与胃癌发生易感性降低显著相关。
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