Lucchi Roberta, Bentanachs Jordi, Oller-Salvia Benjamí
Grup d'Enginyeria de Materials, Institut Químic de Sarrià (IQS), Universitat Ramon Llull, 08017 Barcelona, Spain.
ACS Cent Sci. 2021 May 26;7(5):724-738. doi: 10.1021/acscentsci.0c01448. Epub 2021 Apr 26.
The high selectivity and affinity of antibody binding have made antibodies all-pervasive tools in therapy, diagnosis, and basic science. A plethora of chemogenetic approaches has been devised to make antibodies responsive to stimuli ranging from light to enzymatic activity, temperature, pH, ions, and effector molecules. Within a single decade, the field of activatable antibodies has yielded marketed therapeutics capable of engaging antigens that could not be targeted with traditional antibodies, as well as new tools to control intracellular protein location and investigate biological processes. Many opportunities remain untapped, waiting for more efficient and generally applicable masking strategies to be developed at the interface between chemistry and biotechnology.
抗体结合的高选择性和亲和力使抗体成为治疗、诊断和基础科学中无处不在的工具。人们已经设计出大量化学遗传学方法，使抗体能够对从光到酶活性、温度、pH值、离子和效应分子等各种刺激做出反应。在短短十年内，可激活抗体领域已产生了能够结合传统抗体无法靶向的抗原的上市治疗药物，以及用于控制细胞内蛋白质定位和研究生物过程的新工具。许多机会仍未被开发，等待在化学与生物技术的交叉领域开发出更高效且普遍适用的掩蔽策略。
