Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Suicide Life Threat Behav. 2021 Oct;51(5):897-906. doi: 10.1111/sltb.12768. Epub 2021 Jun 3.
To estimate relative suicidality risk associated with binge-eating disorder (BED).
Retrospective study of patients identified as having BED (N = 1042) and a matched general population cohort (N = 10,420) from the Optum electronic health record database between January 2009 and September 2015. Patients had ≥1 outpatient encounter with a provider who recognized BED during the 12-month baseline preceding entry date. Incidence and relative risk of suicidality were assessed.
Incidence per 1000 person-years (95% CI) of suicidal ideation and suicide attempts, respectively, was 31.1 (23.1, 41.0) and 12.7 (7.9, 19.4) in the BED cohort and 5.8 (4.7, 7.1) and 1.4 (0.9, 2.2) in the comparator cohort. Risk of suicidal ideation and suicide attempts was greater in the BED cohort (HR [95% CIs], 6.43 [4.42, 9.37]) than in the comparator cohort (HR [95% CI], 9.47 [4.99, 17.98]) during follow-up. After adjusting for psychiatric comorbidities, associations of suicidal ideation and suicide attempts with BED remained elevated in patients with BED having histories of suicidality.
Findings suggest that history of suicidality may result in an increased risk of suicidal ideation and suicide attempts in patients with BED relative to the general population. Psychiatric comorbidity burden may explain the elevated risk of these conditions in BED.
评估与暴食障碍（BED）相关的相对自杀风险。
这是一项回顾性研究，研究对象为 2009 年 1 月至 2015 年 9 月期间来自 Optum 电子健康记录数据库的符合以下条件的患者和匹配的一般人群队列：被识别为患有 BED（N=1042）的患者，以及在进入研究日期前的 12 个月基线期内至少有 1 次与识别出 BED 的提供者的门诊就诊记录。评估自杀意念和自杀企图的发生率和相对风险。
BED 队列的自杀意念和自杀企图发生率（每 1000 人年的发生率[95%置信区间]）分别为 31.1（23.1，41.0）和 12.7（7.9，19.4），而对照组分别为 5.8（4.7，7.1）和 1.4（0.9，2.2）。在随访期间，BED 队列的自杀意念和自杀企图风险高于对照组（HR [95% CIs]，6.43 [4.42，9.37]）（HR [95% CI]，9.47 [4.99，17.98]）。在调整了精神共病后，BED 患者的自杀意念和自杀企图与 BED 的关联仍然存在，并且有自杀史的患者风险更高。
这些发现表明，与一般人群相比，自杀史可能导致 BED 患者自杀意念和自杀企图的风险增加。精神共病负担可能解释了 BED 中这些疾病的风险升高。
