Robertson P L, Aldrich M S, Hanash S M, Goldstein G W
Department of Pediatrics, University of Michigan, Ann Arbor 48109.
Ann Neurol. 1988 Jun;23(6):614-6. doi: 10.1002/ana.410230615.
We describe a child with sickle cell anemia and multiple ischemic infarctions who was found to have severe obstructive sleep apnea and hypoxemia, secondary to adenotonsillar enlargement. The apnea-associated hypoxemia likely contributed to the development of the strokes in this child. Moreover, because stroke in patients with sickle cell anemia, and maximal tonsillar enlargement (the most common cause of obstructive apnea in children) both have peak incidence at the same age (6-7 years), obstructive sleep apnea may be an important factor in the development of stroke in other children with sickle cell anemia.
我们描述了一名患有镰状细胞贫血和多处缺血性梗死的儿童，该患儿被发现患有严重的阻塞性睡眠呼吸暂停和低氧血症，继发于腺样体扁桃体肥大。与呼吸暂停相关的低氧血症可能促使了该患儿中风的发生。此外，由于镰状细胞贫血患者的中风以及扁桃体最大程度肿大（儿童阻塞性呼吸暂停最常见的原因）在同一年龄（6 - 7岁）发病率均达到峰值，阻塞性睡眠呼吸暂停可能是其他镰状细胞贫血儿童发生中风的一个重要因素。
