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小儿中耳积液药物治疗的全国质量评估

National Quality Evaluation of Medication Use for Pediatric Otitis Media With Effusion.

作者信息

Chen Yu-Lu, Fang Te-Yung, Wang Pa-Chun, Chen Ya-Hui, Wang Ting-Chuan, Huang Wan-Tsui

机构信息

Department of Pharmacy, Cathay General Hospital, Taipei.

Department of Otolaryngology, Cathay General Hospital, Taipei.

出版信息

Ear Nose Throat J. 2023 Nov;102(11):NP567-NP573. doi: 10.1177/01455613211020531. Epub 2021 Jun 3.

DOI:10.1177/01455613211020531
PMID:34082609
Abstract

OBJECTIVES

Otitis media with effusion (OME) is characterized by the presence of fluid in the middle ear without the presentation of signs or symptoms of acute ear infection. The point prevalence of OME reaches as high as 60% in children younger than 2 years of age. We used the National Health Insurance Research Database (NHIRD) to investigate the use of medication in children with OME before receiving ventilation tube insertion (VTI).

METHODS

Data of pediatric patients (age ≤ 12 years) who had OME and received VTI from January 1, 2011, to December 30, 2012, were retrieved from the Taiwan NHIRD. We surveyed the use of 4 medications to understand whether health care providers achieved the standards of medication use recommended by clinical practice guidelines.

RESULTS

This study examines the factors affecting the use of medication for pediatric OME. Overall, according to the study's operational definitions, the use of systemic antibiotics was most common (59.9%), followed by systemic antihistamines (23.4%), systemic steroids (8.8%), and intranasal steroids (9.6%). Systemic antibiotics use was associated with 12 factors. Ten of the 12 factors increase the use of systemic antibiotics, including namely age (age > 2 years), comorbidities, teaching hospital, and community hospital. In contrast, namely catastrophic illness and watchful waiting are the 2 factors that decrease systemic antibiotics use. For the use of systemic antihistamines, systemic steroids, and intranasal steroids were related to 6, 5, and 2 factors, respectively.

CONCLUSIONS

The rate of drug use differs from the rate of use recommended by commonly used clinical practice guidelines. We found that the higher the number of factors that influenced the patients' drug use, the higher the rate of drug use. According to these results, drafting a treatment guideline for OME patients in accordance with current clinical practices in Taiwan is highly recommended.

摘要

目的

分泌性中耳炎(OME)的特征是中耳有积液,但无急性耳部感染的体征或症状。2岁以下儿童OME的点患病率高达60%。我们使用国民健康保险研究数据库(NHIRD)来调查OME患儿在接受通气管插入术(VTI)之前的用药情况。

方法

从台湾NHIRD中检索2011年1月1日至2012年12月30日期间患有OME并接受VTI的儿科患者(年龄≤12岁)的数据。我们调查了4种药物的使用情况,以了解医疗保健提供者是否达到了临床实践指南推荐的用药标准。

结果

本研究考察了影响儿科OME用药的因素。总体而言,根据该研究的操作定义,全身用抗生素的使用最为常见(59.9%),其次是全身用抗组胺药(23.4%)、全身用类固醇(8.8%)和鼻内用类固醇(9.6%)。全身用抗生素的使用与12个因素相关。这12个因素中有10个会增加全身用抗生素的使用,包括年龄(年龄>2岁)、合并症、教学医院和社区医院。相比之下,重大疾病和观察等待是减少全身用抗生素使用的2个因素。对于全身用抗组胺药、全身用类固醇和鼻内用类固醇的使用,分别与6个、5个和2个因素相关。

结论

药物使用率与常用临床实践指南推荐的使用率不同。我们发现影响患者用药的因素数量越多,用药率越高。根据这些结果,强烈建议根据台湾目前的临床实践为OME患者制定治疗指南。

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