Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
Transplant Center, Leiden University Medical Center, Leiden, the Netherlands.
Nephrol Dial Transplant. 2023 Jun 30;38(7):1707-1718. doi: 10.1093/ndt/gfad023.
Health-related quality of life (HRQOL) is an increasingly important patient-reported outcome in kidney transplant recipients (KTRs). This study explored relationships between symptom prevalence and burden with HRQOL, and age and gender differences in symptom experience.
Eligible Dutch KTRs transplanted in Leiden University Medical Center were invited for this cross-sectional study. HRQOL, and occurrence and burden of 62 symptoms were measured using validated questionnaires. Univariate and multivariate regression analysis were used for investigating the associations of symptom experience with mental and physical HRQOL, and differences in symptom experience between genders and KTRs of diverse age groups.
A total of 631 KTRs were analyzed; the mean (standard deviation) age was 61.3 (11.3) years, and 62% were male. The median (interquartile range) number of symptoms was 14 (7-22), with a burden of 20 (8-37; range 0-244). Per extra symptom, physical and mental HRQOL decreased [-0.41 (-0.50; -0.31) and -0.51 (-0.59; -0.42), respectively, P < .001]. Most occurring symptoms were bruises, tiredness, lack of energy, urge to urinate at night and dry skin. Sexual problems were considered most burdensome. Female KTRs reported more symptoms than men. Amongst others, younger KTRs experienced more (18-50 > 50-65 ≥65 years) feelings of depression and both female and younger KTRs reported higher symptom prevalence concerning changes in physical appearance.
KRTs' symptom experience differed depending on gender and age, highlighting the need to develop tailored treatment strategies to reduce symptom experience and subsequently improve HRQOL.
健康相关生活质量（HRQOL）是肾脏移植受者（KTR）越来越重要的患者报告结果。本研究探讨了症状发生率和负担与 HRQOL 的关系，以及年龄和性别对症状体验的差异。
邀请莱顿大学医学中心接受移植的合格荷兰 KTR 参加这项横断面研究。使用经过验证的问卷测量 HRQOL 以及 62 种症状的发生和负担。使用单变量和多变量回归分析来研究症状体验与心理和生理 HRQOL 的关系，以及性别和不同年龄组 KTR 之间症状体验的差异。
共分析了 631 名 KTR；平均（标准差）年龄为 61.3（11.3）岁，62%为男性。中位数（四分位距）症状数为 14（7-22），负担为 20（8-37；范围 0-244）。每增加一个症状，身体和心理健康状况都会下降[-0.41（-0.50；-0.31）和-0.51（-0.59；-0.42），P<0.001]。最常见的症状是瘀伤、疲倦、乏力、夜间尿频和皮肤干燥。性问题被认为是最负担沉重的问题。女性 KTR 报告的症状比男性多。在其他方面，年轻的 KTR 经历了更多的抑郁情绪（18-50>50-65≥65 岁），并且女性和年轻的 KTR 都报告了更多的与身体外貌变化有关的症状。
KTR 的症状体验因性别和年龄而异，这突出表明需要制定针对特定人群的治疗策略，以减轻症状体验，从而提高 HRQOL。
Zotero 插件
