Department of Pediatrics, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran.
Virol J. 2021 Jun 3;18(1):111. doi: 10.1186/s12985-021-01582-4.
It has been reported that polyomaviruses are the microbes which can be a cause of several human pathological conditions including cancers, nephropathy, progressive multifocal leukoencephalopathy and gynaecological disease. Although investigators proposed some mechanisms used by the viruses to induce the disorders, the roles played by chemokines in the pathogenesis of polyomaviruses infections are yet to be clarified. This review article investigated recent studies regarding the roles played by chemokines in the pathogenesis of the polyomaviruses infections. The research in the literature revealed that CXC chemokines, including CXCL1, CXCL5, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12 and CXCL16, significantly participate in the pathogenesis of polyomaviruses. CC chemokines, such as CCL2, CCL5 and CCL20 also participate in the induction of the pathological conditions. Therefore, it appears that CXC chemokines may be considered as the strategic factors involved in the pathogenesis of polyomaviruses.
已有报道称，多瘤病毒是能够引起多种人类病理状况的微生物，包括癌症、肾病、进行性多灶性白质脑病和妇科疾病。尽管研究人员提出了病毒用于诱导这些疾病的一些机制，但趋化因子在多瘤病毒感染发病机制中的作用仍有待阐明。本文综述了趋化因子在多瘤病毒感染发病机制中的作用的最新研究。文献研究表明，CXC 趋化因子，包括 CXCL1、CXCL5、CXCL8、CXCL9、CXCL10、CXCL11、CXCL12 和 CXCL16，显著参与了多瘤病毒的发病机制。CC 趋化因子，如 CCL2、CCL5 和 CCL20，也参与了病理状况的诱导。因此，CXC 趋化因子似乎可以被认为是多瘤病毒发病机制中的关键因素。
