College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, China; New Rural Development Research Institute of Northwest Normal University, Lanzhou 730070, China.
Orthopaedic Institute, Department of Orthopaedic Surgery, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215006, China.
Mater Sci Eng C Mater Biol Appl. 2021 Jul;126:112171. doi: 10.1016/j.msec.2021.112171. Epub 2021 May 6.
The lack of antibacterial properties limits the application of bacterial cellulose hydrogels in wound dressings. To overcome this deficiency, silver nanoparticles (AgNPs) were introduced as antibacterial agents into a polyvinyl alcohol (PVA)/bacterial cellulose (BC) solution. A freeze-thaw method promoted formation of PVA/BC/Ag hydrogels and improved their mechanical properties. The physicochemical and biological properties of this hydrogel were systematically characterized. Those results showed the hydrogels contained a porous three-dimensional reticulum structure and had high mechanical properties. Also, the hydrogels possessed outstanding antibacterial properties and good biocompatibilities. More importantly, it effectively repaired wound defects in mice models and wound healing reached 97.89% within 15 days, and far exceeded other groups and indicated its potential for use in wound treatment applications.
细菌纤维素水凝胶缺乏抗菌性能，限制了其在伤口敷料中的应用。为了克服这一缺陷，将银纳米粒子 (AgNPs) 作为抗菌剂引入到聚乙烯醇 (PVA)/细菌纤维素 (BC) 溶液中。通过冻融法促进了 PVA/BC/Ag 水凝胶的形成，并提高了其机械性能。系统地表征了这种水凝胶的物理化学和生物学性质。结果表明，水凝胶含有多孔的三维网状结构，具有较高的机械性能。此外，水凝胶具有优异的抗菌性能和良好的生物相容性。更重要的是，它能有效修复小鼠模型中的伤口缺陷，在 15 天内伤口愈合率达到 97.89%，远远超过其他组，表明其在伤口治疗应用中的潜力。
