文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

载银纳米粒子的壳聚糖-g-PVA 水凝胶在创伤愈合中的应用。

Silver Nanoparticles Loaded on Chitosan-g-PVA Hydrogel for the Wound-Healing Applications.

机构信息

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Clinical Laboratory Sciences Program, Inaya Medical College, Riyadh 12211, Saudi Arabia.

出版信息

Molecules. 2023 Apr 5;28(7):3241. doi: 10.3390/molecules28073241.

DOI:10.3390/molecules28073241
PMID:37050003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10096253/
Abstract

Silver nanoparticle composites have abundant biomedical applications due to their unique antibacterial properties. In the current work, green tea leaf extract was used as a natural reducing agent to synthesize AgNPs (AgNPs) using microwave irradiation technology. Furthermore, microwave irradiation has been used for the preparation of AgNPs/chitosan (Ch) grafted polyvinyl alcohol (PVA) hydrogel samples. To approve the accomplishment of AgNPs hydrogel polymer, UV-spectrum, TEM, and FT-IR spectrum analyses and the release of silver ions, actions were taken. The wound-healing ability of the prepared hydrogel samples was measured via both the in vitro (fibroblast cells) and the in vivo using rat models. It was found that chitosan-grafted polyvinyl alcohol, including AgNPs, exhibited excellent antibacterial activity against and using the agar diffusion method. It can be said that microwave irradiation was successful in creating a hydrogel that contained silver nanoparticles. A wound that was still open was successfully treated with these composites.

摘要

由于其独特的抗菌性能，银纳米粒子复合材料在生物医学领域有广泛的应用。在本工作中，采用绿茶提取物作为天然还原剂，通过微波辐射技术合成了银纳米粒子（AgNPs）。此外，还采用微波辐射技术制备了AgNPs/壳聚糖（Ch）接枝聚乙烯醇（PVA）水凝胶样品。为了证实 AgNPs 水凝胶聚合物的形成，进行了 UV 光谱、TEM、FT-IR 光谱分析和银离子释放实验。通过体外（成纤维细胞）和体内（大鼠模型）实验评估了所制备水凝胶样品的愈合能力。结果表明，通过琼脂扩散法，接枝有壳聚糖的聚乙烯醇包括 AgNPs 对 和 具有优异的抗菌活性。可以说，微波辐射成功地制备了含有银纳米粒子的水凝胶。这些复合材料成功地治疗了尚未愈合的伤口。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/8a1fae33b94d/molecules-28-03241-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/7191fe81b43f/molecules-28-03241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/66f1ff6bcb8d/molecules-28-03241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/f89f3966c71b/molecules-28-03241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/fd46192b7307/molecules-28-03241-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/8e1cec689d3d/molecules-28-03241-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/25a2c19f492d/molecules-28-03241-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/042044235dc1/molecules-28-03241-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/57332fd714fb/molecules-28-03241-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/d33c02e293d5/molecules-28-03241-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/8a1fae33b94d/molecules-28-03241-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/7191fe81b43f/molecules-28-03241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/66f1ff6bcb8d/molecules-28-03241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/f89f3966c71b/molecules-28-03241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/fd46192b7307/molecules-28-03241-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/8e1cec689d3d/molecules-28-03241-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/25a2c19f492d/molecules-28-03241-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/042044235dc1/molecules-28-03241-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/57332fd714fb/molecules-28-03241-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/d33c02e293d5/molecules-28-03241-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a98/10096253/8a1fae33b94d/molecules-28-03241-g010.jpg

相似文献

[1]
Silver Nanoparticles Loaded on Chitosan-g-PVA Hydrogel for the Wound-Healing Applications.

Molecules. 2023-4-5

[2]
Silver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits.

Int J Pharm. 2019-1-19

[3]
Polyvinyl alcohol/carboxymethyl chitosan hydrogel loaded with silver nanoparticles exhibited antibacterial and self-healing properties.

Int J Biol Macromol. 2022-11-1

[4]
Synthesis of physically crosslinked PVA/Chitosan loaded silver nanoparticles hydrogels with tunable mechanical properties and antibacterial effects.

Int J Biol Macromol. 2020-2-7

[5]
Synthesis of nanocomposite hydrogel based carboxymethyl starch/polyvinyl alcohol/nanosilver for biomedical materials.

Carbohydr Polym. 2020-11-15

[6]
Synthesis of silver/FeO@chitosan@polyvinyl alcohol magnetic nanoparticles as an antibacterial agent for accelerating wound healing.

Int J Biol Macromol. 2022-11-30

[7]
Wound healing applications of sericin/chitosan-capped silver nanoparticles incorporated hydrogel.

Drug Deliv Transl Res. 2017-2

[8]
Fabrication and durable antibacterial properties of electrospun chitosan nanofibers with silver nanoparticles.

Int J Biol Macromol. 2015-8

[9]
Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study.

Int J Nanomedicine. 2013-11-1

[10]
Sprayed in-situ synthesis of polyvinyl alcohol/chitosan loaded silver nanocomposite hydrogel for improved antibacterial effects.

Int J Biol Macromol. 2019-10-24

引用本文的文献

[1]
Advancements in Hydrogels: A Comprehensive Review of Natural and Synthetic Innovations for Biomedical Applications.

Polymers (Basel). 2025-7-24

[2]
Biodegradable chitosan/PVA-based hydrogel incorporating green synthesized silver nanoparticles for wound healing applications.

BMC Chem. 2025-7-3

[3]
Advancements in silver-based nanocatalysts for organic transformations and other applications: a comprehensive review (2019-2024).

RSC Adv. 2025-5-27

[4]
Fabrication of gelatine/fucoidan nanogel-coated silver nanoparticles for the treatment of wound healing therapy and nursing care.

Regen Ther. 2025-3-29

[5]
Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings.

Gels. 2025-2-7

[6]
Reducing the effective dose of doxycycline using chitosan silver nanocomposite as a carriers on gram positive and gram-negative bacteria.

Sci Rep. 2024-11-13

[7]
Gamma-irradiated copper-based metal organic framework nanocomposites for photocatalytic degradation of water pollutants and disinfection of some pathogenic bacteria and fungi.

BMC Microbiol. 2024-11-6

[8]
Silver Nanoparticles in Therapeutics and Beyond: A Review of Mechanism Insights and Applications.

Nanomaterials (Basel). 2024-10-10

[9]
Lyophilized Polyvinyl Alcohol and Chitosan Scaffolds Pre-Loaded with Silicon Dioxide Nanoparticles for Tissue Regeneration.

Molecules. 2024-8-14

[10]
Silver/tannic acid nanoparticles/ poly-L-lysine decorated polyvinyl alcohol-hydrogel as a hybrid wound dressing.

Heliyon. 2024-7-26

本文引用的文献

[1]
Gallic acid functionalized chitosan immobilized nanosilver for modified chitosan/Poly (vinyl alcohol) composite film.

Int J Biol Macromol. 2022-12-1

[2]
Curcumin Sustained Release with a Hybrid Chitosan-Silk Fibroin Nanofiber Containing Silver Nanoparticles as a Novel Highly Efficient Antibacterial Wound Dressing.

Nanomaterials (Basel). 2022-9-29

[3]
Silver Nanoparticle-Based Combinations with Antimicrobial Agents against Antimicrobial-Resistant Clinical Isolates.

Antibiotics (Basel). 2022-9-8

[4]
Synthesis of silver/FeO@chitosan@polyvinyl alcohol magnetic nanoparticles as an antibacterial agent for accelerating wound healing.

Int J Biol Macromol. 2022-11-30

[5]
Progress in Antibacterial Hydrogel Dressing.

Gels. 2022-8-12

[6]
Polyvinyl alcohol/carboxymethyl chitosan hydrogel loaded with silver nanoparticles exhibited antibacterial and self-healing properties.

Int J Biol Macromol. 2022-11-1

[7]
Green synthesis of bioinspired chitosan-ZnO-based polysaccharide gums hydrogels with propolis extract as novel functional natural biomaterials.

Int J Biol Macromol. 2022-6-30

[8]
Evaluation of Antimicrobial and Anti-Biofilm Formation Activities of Novel Poly(vinyl alcohol) Hydrogels Reinforced with Crosslinked Chitosan and Silver Nano-Particles.

Polymers (Basel). 2022-4-16

[9]
Polyvinyl Alcohol/Sodium Alginate Hydrogels Incorporated with Silver Nanoclusters via Green Tea Extract for Antibacterial Applications.

Des Monomers Polym. 2020-8-5

[10]
Silver Nanomaterials for Wound Dressing Applications.

Pharmaceutics. 2020-8-28

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索