Werneck L C
Departamento de Cliníca Médica, Universidade Federal do Paraná, Curitiba, Brasil.
Arq Neuropsiquiatr. 1988 Mar;46(1):22-8. doi: 10.1590/s0004-282x1988000100006.
Results of 89 peripheral nerve biopsies studied only by paraffin sections are analysed to determine the abnormalities incidence, and in what extent a general pathology laboratory can help in final diagnosis of patients with peripheral nerve disorders. 37% normal nerve biopsies and 63% with some histological alteration were found; only in 22% the nosological diagnosis was possible. A discussion about the low incidence of nosological diagnosis is made, and a literature revision on routine nerve biopsies. It is concluded that nerve biopsies should be done only in special cases, particularly when other diagnostic methods failed, taking into account always the limitation of the method, and preferentially studying a clinically involved nerve.
对仅通过石蜡切片研究的89例周围神经活检结果进行分析，以确定异常发生率，以及普通病理实验室在多大程度上有助于周围神经疾病患者的最终诊断。结果发现，37%的神经活检结果正常，63%存在一些组织学改变；只有22%的病例能够做出病因学诊断。文中对病因学诊断低发生率进行了讨论，并对常规神经活检的文献进行了综述。结论是，神经活检仅应在特殊情况下进行，特别是在其他诊断方法失败时，要始终考虑到该方法的局限性，优先对临床上受累的神经进行研究。
