Using carboxymethyl gum from and seeds with leaf extract to develop antibacterial gauze dressing with hemostatic activity.

BACKGROUND AND PURPOSE

Gauze dressing is a barrier against microbial infection in wounds. The seed gums of and are abundant in tropical countries; we used them as a coating material of cotton gauzes to improve the liquid absorption ability. Moreover, leaf extract was loaded on the gums for antibacterial gauze dressing with hemostatic activity.

EXPERIMENTAL APPROACH

Crude gums were extracted from and seeds and carboxymethyl gums were then derived and chracterized. C. Odorata ethanolic extract was also prepared by maceration and its antimicrobial and blood clotting activities were determine coated gauze dressing containing different concentrations of carboxymethyl gum was prepared in the presence of various concentrations of extract. Then, the physical properties, antibacterial activity, and skin-irritating effects of the coated gauze were analyzed.

FINDINGS/RESULTS: The results indicated that the amount of carboxymethyl gum affected the physical properties and absorption capacity of the coated gauze. extract exhibited better bactericidal activity against than against . The blood clotting effects of extract indicated that it had dramatic hemostatic efficacy. The coated gauze exhibited bactericidal activity against . In the human skin irritation test, the coated gauze caused no adverse effects on human skin.

CONCLUSION AND IMPLICATION

Coated gauze has the potential to serve as a prototype for primary hemostasis in first aid for opened wounds such as abrasions and lacerations.