Potes Mark Immanuel, Joaquin Christian, Wiecks Nicole, Phan Sheshanna, Hassan Omron
Department of Medical Education, School of Medicine, California University of Science and Medicine, Colton, California, United States.
Department of Clinical Education, Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania, United States.
Surg Neurol Int. 2021 Apr 19;12:169. doi: 10.25259/SNI_730_2020. eCollection 2021.
Deep brain stimulation (DBS) has demonstrated preliminary success as a treatment for neuropsychological disorders including obsessive-compulsive disorder and substance use disorder. This systematic review aims to assess the use of DBS in treating eating disorders (EDs) to determine its utility and the extent of adverse effects.
A PubMed search following PRISMA guidelines was executed to find studies encompassing DBS as a treatment of ED. Outcomes were extracted from the literature and summarized while a review of quality was also performed.
From a search yielding 299 publications, 11 studies published between 2010 and 2020 were found to fit the inclusion criteria. Out of 53 patients who began with an abnormal BMI before treatment, 22 patients (41.5%) achieved normal BMI on follow-up. Significant neuropsychological improvement was seen in most patients as measured by neuropsychiatric testing and questionnaires.
DBS as a treatment for ED may result in significant objective and psychological benefits. Further studies should aim to increase the sample size, standardize follow-up protocol, and standardize the neuropsychiatric tests used to determine psychological and physiological benefits.
深部脑刺激（DBS）已初步证明可成功治疗包括强迫症和物质使用障碍在内的神经心理障碍。本系统评价旨在评估DBS在治疗饮食失调（ED）中的应用，以确定其效用和不良反应的程度。
按照PRISMA指南在PubMed上进行检索，以查找包含DBS治疗ED的研究。从文献中提取结果并进行总结，同时对质量进行评估。
在检索出的299篇出版物中，发现2010年至2020年间发表的11项研究符合纳入标准。在治疗前BMI异常的53例患者中，22例（41.5%）在随访时BMI恢复正常。通过神经精神测试和问卷调查发现，大多数患者的神经心理状况有显著改善。
DBS治疗ED可能会带来显著的客观和心理益处。进一步的研究应旨在增加样本量、规范随访方案，并规范用于确定心理和生理益处的神经精神测试。
