Amelianchik Anna, Merkel Jonathan, Palanisamy Premkumar, Kaneki Shigeru, Hyatt Emily, Norris Erin H
Patricia and John Rosenwald Laboratory of Neurobiology and Genetics The Rockefeller University New York USA.
Paul Flechsig Institute of Brain Research Leipzig University Leipzig Germany.
Alzheimers Dement (N Y). 2021 May 25;7(1):e12173. doi: 10.1002/trc2.12173. eCollection 2021.
It has been suggested that obesity may influence Alzheimer's disease (AD) pathogenesis, yet the numerous publications on this topic have inconsistent results and conclusions.
Our study examined the effect of varying the timing of high-fat diet (HFD) consumption on AD-related pathology and cognition in transgenic Tg6799 AD mice.
HFD feeding starting at or before 3 months of age, prior to severe AD pathology, had protective effects in AD mice: reduced extracellular amyloid beta (Aβ) deposition, decreased fibrinogen extravasation into the brain parenchyma, and improved cognitive function. However, delaying HFD consumption until 6 months of age, when AD pathology is ubiquitous, reduced these protective effects in AD mice.
Overall, we demonstrate that the timeline of HFD consumption may play an important role in how dietary fats affect AD pathogenesis and cognitive function.
有人认为肥胖可能会影响阿尔茨海默病（AD）的发病机制，但关于这一主题的众多出版物结果和结论并不一致。
我们的研究检测了在转基因Tg6799 AD小鼠中，改变高脂饮食（HFD）摄入时间对AD相关病理和认知的影响。
在3个月龄及之前（即严重AD病理出现之前）开始高脂饮食喂养，对AD小鼠具有保护作用：减少细胞外β淀粉样蛋白（Aβ）沉积，减少纤维蛋白原渗入脑实质，并改善认知功能。然而，将高脂饮食的摄入推迟到6个月龄，此时AD病理普遍存在，则会降低对AD小鼠的这些保护作用。
总体而言，我们证明了高脂饮食摄入的时间线可能在膳食脂肪影响AD发病机制和认知功能的方式中起重要作用。
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