Galdieri M, Faraonio R, Colantuoni V
Istituto di Istologia ed Embriologia Generale, Università di Roma, La Sapienza.
Biochem Biophys Res Commun. 1988 Aug 15;154(3):1174-81. doi: 10.1016/0006-291x(88)90264-1.
A cDNA clone coding for Cellular Retinol-Binding Protein (CRBP) was used as a probe to study the expression of the gene in the somatic cells of the seminiferous tubules (Sertoli and peritubular cells). In this paper we demonstrate that these cells are actively involved in the synthesis of the specific mRNA. In Sertoli cells the gene is modulated by the hormones effective in spermatogenesis, such as FSH and testosterone. Moreover, peritubular cells revealed an approximately two times higher concentration of CRBP steady-state mRNA levels when compared with Sertoli cells.
一个编码细胞视黄醇结合蛋白（CRBP）的cDNA克隆被用作探针，以研究该基因在生精小管（支持细胞和管周细胞）体细胞中的表达。在本文中，我们证明这些细胞积极参与特定mRNA的合成。在支持细胞中，该基因受对精子发生有效的激素（如促卵泡激素和睾酮）调节。此外，与支持细胞相比，管周细胞中CRBP稳态mRNA水平的浓度大约高两倍。
