Division of Drug Development, MirZyme Therapeutics, Birmingham, UK.
Department of Cardiology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Br J Pharmacol. 2022 May;179(10):2108-2120. doi: 10.1111/bph.15582. Epub 2021 Jul 6.
Emerging data show that pregnant women with COVID-19 are at significantly higher risk of severe outcomes compared with non-pregnant women of similar age. This review discusses the invaluable insight revealed from vaccine clinical trials in women who were vaccinated and inadvertently became pregnant during the trial period. It further explores a number of clinical avenues in their management and proposes a drug development strategy in line with clinical trials for vaccines and drug treatments for the drug development community. Little is known of the long-term effects of COVID-19 on the mother and the baby. Our hypothesis that COVID-19 predisposes pregnant women to pre-eclampsia or hypertensive disorders during pregnancy is supported by a clinical study, and this may also adversely impact a woman's cardiovascular disease risk later in life. It may also increase a woman's risk of pre-eclampsia in subsequent pregnancy. This is an ever-evolving landscape, and early knowledge for healthcare providers and drug innovators is offered to ensure benefits outweigh the risks. COVID-19 mRNA vaccines appear to generate robust humoral immunity in pregnant and lactating women. This novel approach to vaccination also offers new ways to therapeutically tackle disorders of many unmet medical needs. LINKED ARTICLES: This article is part of a themed issue on The second wave: are we any closer to efficacious pharmacotherapy for COVID 19? (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.10/issuetoc.
新兴数据表明，与年龄相仿的未怀孕女性相比，COVID-19 孕妇发生重症的风险明显更高。本综述讨论了疫苗临床试验中令人瞩目的发现，这些女性在试验期间接种疫苗后意外怀孕。本综述进一步探讨了针对这些女性的若干临床处理途径，并为疫苗和药物治疗的临床试验提出了药物研发策略，为药物研发界提供参考。目前对于 COVID-19 对母亲和婴儿的长期影响知之甚少。我们的假设是 COVID-19 使孕妇在怀孕期间更容易患上子痫前期或高血压疾病，这一假设得到了一项临床研究的支持，这也可能对女性以后的心血管疾病风险产生不利影响。它还可能增加女性在随后妊娠中患上子痫前期的风险。这是一个不断发展的领域，为医疗保健提供者和药物创新者提供早期知识，以确保收益大于风险。COVID-19 mRNA 疫苗似乎在孕妇和哺乳期妇女中产生了强大的体液免疫。这种新的疫苗接种方法还为治疗许多未满足医疗需求的疾病提供了新的途径。相关文章：本文是关于“第二波：我们离 COVID-19 的有效药物治疗更近了吗？”这一主题的特刊的一部分（BJP 第 75 周年）。要查看本部分中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.10/issuetoc.
