Liu Yang, Mu Qingxuan, Shi Ya'nan, Yu Bo
CAS Key Laboratory of Microbial Physiological & Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Sheng Wu Gong Cheng Xue Bao. 2021 May 25;37(5):1541-1563. doi: 10.13345/j.cjb.200688.
The regulation of the expression of genes involved in metabolic pathways, termed as metabolic regulation, is vital to construct efficient microbial cell factories. With the continuous breakthroughs in synthetic biology, the mining and artificial design of high-quality regulatory elements have substantially improved our ability to modify and regulate cellular metabolic networks and its activities. The research on metabolic regulation has also evolved from the static regulation of single genes to the intelligent and precise dynamic regulation at the systems level. This review briefly summarizes the advances of metabolic regulation technologies in the past 30 years.
参与代谢途径的基因表达调控，即代谢调控，对于构建高效的微生物细胞工厂至关重要。随着合成生物学的不断突破，高质量调控元件的挖掘和人工设计极大地提高了我们修饰和调控细胞代谢网络及其活性的能力。代谢调控的研究也已从单个基因的静态调控发展到系统水平的智能精准动态调控。本文简要总结了过去30年代谢调控技术的进展。
