Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain; SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain.
Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain; SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain.
Neurosci Biobehav Rev. 2021 Sep;128:394-405. doi: 10.1016/j.neubiorev.2021.05.025. Epub 2021 Jun 1.
Neurodegenerative disorders are associated with reduced levels of brain-derived neurotrophic factor (BDNF). We aimed to assess the effect of exercise interventions on plasma BDNF levels in individuals with neurodegenerative disorders. Eighteen randomized controlled trials (RCT) assessing the effects of exercise interventions versus no exercise on plasma BDNF levels in individuals with neurodegenerative disorders (i.e., multiple sclerosis, Parkinson's disease, mild cognitive impairment [MCI] and Alzheimer's disease) were included. Overall, exercise interventions induced a significant increase in plasma BDNF levels (SMD=2.22, 95% CI=1.33-3.12, p<0.001; 18 studies), which was separately confirmed for multiple sclerosis (SMD= 2.40, 95% CI= 1.30-3.50, p<0.001; 10 studies) and Parkinson's disease (SMD= 10.00, 95% CI= 2.48-17.51, p=0.009; 3 studies), with a non-significant trend also observed for MCI (SMD= 1.07, 95% CI= -0.14-2.28, p=0.080; 4 studies). BDNF levels significantly increased regardless of exercise type (p<0.001, p=0.003 and p=0.020 for combined, aerobic and resistance exercise, respectively), weekly exercise volume (p<0.001 for both ≥150 and <150 min/week) and intervention length (p<0.001 for both interventions of ≥12 and <12 weeks). In conclusion, physical exercise interventions increase plasma BDNF levels in individuals with neurodegenerative disorders. PROSPERO registration number: CRD42020199459.
神经退行性疾病与脑源性神经营养因子 (BDNF) 水平降低有关。我们旨在评估运动干预对神经退行性疾病患者血浆 BDNF 水平的影响。纳入了 18 项随机对照试验 (RCT)，评估了运动干预与无运动对神经退行性疾病患者（即多发性硬化症、帕金森病、轻度认知障碍 [MCI] 和阿尔茨海默病）血浆 BDNF 水平的影响。总的来说，运动干预显著增加了血浆 BDNF 水平（SMD=2.22，95%CI=1.33-3.12，p<0.001；18 项研究），这在多发性硬化症（SMD=2.40，95%CI=1.30-3.50，p<0.001；10 项研究）和帕金森病（SMD=10.00，95%CI=2.48-17.51，p=0.009；3 项研究）中得到了单独证实，MCI 也呈现出非显著趋势（SMD=1.07，95%CI=-0.14-2.28，p=0.080；4 项研究）。无论运动类型（联合、有氧和抗阻运动，p<0.001、p=0.003 和 p=0.020）、每周运动量（≥150 分钟/周和<150 分钟/周，p<0.001）和干预时长（≥12 周和<12 周，p<0.001）如何，BDNF 水平均显著增加。总之，身体运动干预可增加神经退行性疾病患者的血浆 BDNF 水平。PROSPERO 注册号：CRD42020199459。
