CICS-UBI - Health Sciences Research Centre, University of Beira Interior, University of Beira Interior, Covilhã, Portugal; FCS-UBI, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
CICS-UBI - Health Sciences Research Centre, University of Beira Interior, University of Beira Interior, Covilhã, Portugal.
Environ Pollut. 2021 Sep 15;285:117475. doi: 10.1016/j.envpol.2021.117475. Epub 2021 May 31.
Hexabromocyclododecane (HBCD) and Tetrabromobisphenol A (TBBP-A) are brominated flame retardants widely used in variety of industrial and consumer products (e.g., automobiles, electronics, furniture, textiles and plastics) to reduce flammability. HBCD and TBBPA can also contaminate the environment, mainly water, dust, air and soil, from which human exposure occurs. This constant exposure has raised some concerns against human health. These compounds can act as endocrine disruptors, a property that gives them the ability to interfere with hormonal function and quantity, when HBCD and TBBPA bind target tissues in the body. Studies in human and animals suggest a correlation between HBCD and TBBPA exposure and adverse health outcomes, namely thyroid disorders, neurobehavior and development disorders, reproductive health, immunological, oncological and cardiovascular diseases. However, in humans these effects are still poorly understood, once only a few data evaluated the human health effects. Thus, the purpose of this review is to present the toxicity effects of HBCD and TBBPA and how these compounds affect the environment and health, resorting to data and knowledge of 255 published papers from 1979 to 2020.
六溴环十二烷（HBCD）和四溴双酚 A（TBBP-A）是两种广泛应用于各种工业和消费品（如汽车、电子、家具、纺织品和塑料）的溴系阻燃剂，以降低可燃性。HBCD 和 TBBPA 也会污染环境，主要是水、灰尘、空气和土壤，人类会因此接触到这些污染物。这种持续的暴露引起了人们对健康的一些担忧。这些化合物可以作为内分泌干扰物，当 HBCD 和 TBBPA 与体内的靶组织结合时，这种特性使它们能够干扰激素功能和数量。在人类和动物的研究中，HBCD 和 TBBPA 的暴露与甲状腺疾病、神经行为和发育障碍、生殖健康、免疫、肿瘤和心血管疾病等不良健康结果之间存在相关性。然而，在人类中，这些影响仍知之甚少，因为只有少数数据评估了人类健康的影响。因此，本综述的目的是介绍 HBCD 和 TBBPA 的毒性作用，以及这些化合物如何通过数据和知识影响环境和健康，这些数据和知识来源于 1979 年至 2020 年期间发表的 255 篇论文。
