School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Horm Behav. 2021 Jul;133:105006. doi: 10.1016/j.yhbeh.2021.105006. Epub 2021 Jun 1.
Obesity is strongly related to leptin resistance that refers to the state in which leptin fails to inhibit appetite, enhance energy expenditure and regulate glycolipid metabolism, whereas decreasing leptin resistance is important for obesity treatment. Leptin resistance that develops in brain and also directly in peripheral tissues is considered as central and peripheral leptin resistance, respectively. The mechanism of central leptin resistance is the focus of intensive studies but still not totally clarified. A challenged notion about the effect of impaired leptin BBB transport emerges and a concept of "selective leptin resistance" is discussed. Peripheral leptin resistance, especially leptin resistance in muscle, has drawn more attention recently, while its mechanism remains unclear. Exercise is an effective way to reduce obesity, which is at least in part due to the alleviation of leptin resistance. Here, we summarized newly discovered data about the associated factors of central leptin resistance and peripheral leptin resistance, and the actions of exercise on leptin resistance, which is important to understand the mechanisms of leptin resistance and exercise-induced alleviation of leptin resistance, and to facilitate clinical application of leptin in obesity treatment.
肥胖与瘦素抵抗密切相关，瘦素抵抗是指瘦素不能抑制食欲、增强能量消耗和调节糖脂代谢的状态，而降低瘦素抵抗对肥胖治疗很重要。在大脑中以及外周组织中直接发生的瘦素抵抗分别被认为是中枢性和外周性瘦素抵抗。中枢性瘦素抵抗的机制是目前研究的重点，但仍未完全阐明。关于血脑屏障转运受损的瘦素作用的一个有争议的观点出现了，并且提出了“选择性瘦素抵抗”的概念。最近，人们对外周性瘦素抵抗，尤其是肌肉中的瘦素抵抗越来越关注，但其机制尚不清楚。运动是减轻肥胖的有效方法，这至少部分归因于瘦素抵抗的减轻。在这里，我们总结了关于中枢性和外周性瘦素抵抗相关因素以及运动对瘦素抵抗的作用的新发现数据，这对于理解瘦素抵抗和运动减轻瘦素抵抗的机制以及促进瘦素在肥胖治疗中的临床应用很重要。
