Rothman R H, Clark A J
Mol Gen Genet. 1977 Oct 24;155(3):279-86. doi: 10.1007/BF00272806.
Mutants carrying recF143 or recF144 show wild type levels of host cell reactivation of UV-irradiated lambdavir and wild type rates of excision gap closure in repairing UV damage to their own DNA. The same mutants showed reduced rates of postreplication repair strand joining. When uvrA- recF- or uvrB- recF- strains are tested, postreplication repair strand joining is incomplete or does not occur at fluences above 1 J/m2. We suggest that there may be a UvrAB and a RecF pathway of postreplication repair or that the repair functions controlled or determined by uvrA uvrB and by recF may be similar. An intermediate in postreplication repair may accumulate in the uvr- recF- strain.
携带recF143或recF144的突变体对紫外线照射的λ噬菌体显示出野生型水平的宿主细胞复活能力，并且在修复自身DNA的紫外线损伤时具有野生型的切除缺口闭合速率。相同的突变体显示出复制后修复链连接速率降低。当测试uvrA- recF- 或uvrB- recF- 菌株时，在高于1 J/m2的通量下，复制后修复链连接不完整或不发生。我们认为可能存在复制后修复的UvrAB和RecF途径，或者由uvrA、uvrB和recF控制或决定的修复功能可能相似。复制后修复的一种中间体可能在uvr- recF- 菌株中积累。
