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急性黄疸型肝炎为 COVID-19 的首发孤立症状。

Acute icteric hepatitis as the first isolated symptom of COVID-19.

机构信息

Emergency Department, Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris, Sorbonne Université, Paris, France

Emergency Department, Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris, Sorbonne Université, Paris, France.

出版信息

BMJ Case Rep. 2021 Jun 4;14(6):e242853. doi: 10.1136/bcr-2021-242853.

DOI:10.1136/bcr-2021-242853
PMID:34088694
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8183276/
Abstract

Patients with COVID-19 may be asymptomatic or present with extrarespiratory symptoms, such as liver injury. It has been reported that 22.5%-46.2% of patients have moderate elevation of liver enzymes. To our knowledge, acute hepatitis has never been described as an isolated symptom of COVID-19 in a previously healthy patient. We report the case of a 53-year-old patient with COVID-19 whose first clinical presentation was acute icteric hepatitis, several days before the development of others symptoms. During the pandemic, we suggest that patients with acute hepatitis be considered as COVID-19 suspects, tested and isolated.

摘要

COVID-19 患者可能无症状或表现出呼吸外症状,如肝损伤。据报道,22.5%-46.2%的患者肝酶中度升高。据我们所知,急性肝炎从未被描述为既往健康患者 COVID-19 的孤立症状。我们报告了一例 COVID-19 患者,其首次临床表现为急性黄疸性肝炎,在出现其他症状的前几天。在大流行期间,我们建议将急性肝炎患者视为 COVID-19 疑似病例,进行检测和隔离。

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本文引用的文献

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World J Hepatol. 2020 Dec 27;12(12):1182-1197. doi: 10.4254/wjh.v12.i12.1182.
2
Diagnostic Value of Patient-Reported and Clinically Tested Olfactory Dysfunction in a Population Screened for COVID-19.患者报告和临床测试嗅觉功能障碍在 COVID-19 筛查人群中的诊断价值。
JAMA Otolaryngol Head Neck Surg. 2021 Mar 1;147(3):271-279. doi: 10.1001/jamaoto.2020.5074.
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Pathophysiological mechanisms of liver injury in COVID-19.COVID-19 相关肝损伤的病理生理机制。
Liver Int. 2021 Jan;41(1):20-32. doi: 10.1111/liv.14730. Epub 2020 Nov 29.
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COVID-19 presenting as fulminant hepatic failure: A case report.以暴发性肝衰竭为表现的新型冠状病毒肺炎:一例报告
Medicine (Baltimore). 2020 Oct 23;99(43):e22818. doi: 10.1097/MD.0000000000022818.
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Acute hepatitis caused by asymptomatic COVID-19 infection.无症状新冠病毒感染所致急性肝炎
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Running out of bullets: The challenging management of acute hepatitis and SARS-COV-2 from the SMatteo COvid19 Registry (SMACORE).弹药用尽:来自 SMatteo COVID19 注册研究(SMACORE)的急性肝炎和 SARS-COV-2 的挑战性管理。
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Liver injury is independently associated with adverse clinical outcomes in patients with COVID-19.肝损伤与 COVID-19 患者的不良临床结局独立相关。
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