Anirvan Prajna, Bharali Pankaj, Gogoi Mrinal, Thuluvath Paul J, Singh Shivaram P, Satapathy Sanjaya K
Department of Gastroenterology, Sriram Chandra Bhanj Medical College, Cuttack 753007, Odisha, India.
Department of Gastroenterology, Sriram Chandra Bhanj Medical College and Hospital, Cuttack 753007, Odisha, India.
World J Hepatol. 2020 Dec 27;12(12):1182-1197. doi: 10.4254/wjh.v12.i12.1182.
The 2019 novel coronavirus disease (COVID-19) pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to global public health. Although primarily, the infection causes lung injury, liver enzyme abnormalities have also been reported to occur during the course of the disease. We conducted an extensive literature review using the PubMed database on articles covering a broad range of issues related to COVID-19 and hepatic injury. The present review summarizes available information on the spectrum of liver involvement, the possible mechanisms and risk factors of liver injury due to SARS-CoV-2 infection, and the prognostic significance of the presence of liver injury. Hopefully, this review will enable clinicians, especially the hepatologists, to understand and manage the liver derangements they may encounter in these patients better and provide guidance for further studies on the liver injury of COVID-19.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019年新型冠状病毒病（COVID-19）大流行对全球公共卫生构成了严重威胁。虽然主要是感染导致肺损伤，但在疾病过程中也有肝酶异常的报道。我们使用PubMed数据库对涵盖与COVID-19和肝损伤相关的广泛问题的文章进行了广泛的文献综述。本综述总结了关于肝脏受累范围、SARS-CoV-2感染导致肝损伤的可能机制和危险因素以及肝损伤存在的预后意义的现有信息。希望本综述能使临床医生，尤其是肝病学家，更好地理解和处理他们在这些患者中可能遇到的肝脏紊乱，并为进一步研究COVID-19的肝损伤提供指导。
