Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Department of Pathology, Eastern Medical College & Hospital, Cumilla, Bangladesh.
Cancer Rep (Hoboken). 2022 Feb;5(2):e1473. doi: 10.1002/cnr2.1473. Epub 2021 Jun 5.
Hodgkin's lymphoma (HL) with skin involvement is reasonably rare. It typically occurs late in the course and is associated with a poor prognosis; however, it may also be indolent in some cases.
We report a case of a 15-year-old previously healthy male with Hodgkin's lymphoma who presented with multiple lymphadenopathies of axilla and serpiginous ulcerative nodular lesions involving pectoral skin. A lymph node biopsy was performed following an initial diagnostic workup for a suspected active infectious disease, which revealed a neoplastic invasion from a mixed cellularity classical HL with skin involvement. A total of six cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy regimen was administered to the patient.
In comparison to other studies, this case demonstrates that a good response is possible with standard ABVD chemotherapy.
伴有皮肤累及的霍奇金淋巴瘤（HL）较为罕见。它通常发生在病程晚期，预后不良；然而，在某些情况下也可能是惰性的。
我们报告了一例 15 岁的既往健康男性，患有霍奇金淋巴瘤，表现为腋窝多发性淋巴结病和累及胸皮的匐行性溃疡性结节性病变。在最初疑似活动性传染病的诊断性检查后进行了淋巴结活检，结果显示混合细胞性经典 HL 伴皮肤累及的肿瘤浸润。共对患者进行了六个周期的 ABVD（多柔比星、博来霉素、长春碱和达卡巴嗪）化疗方案。
与其他研究相比，该病例表明标准 ABVD 化疗可能会有较好的反应。
