Cancer Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Internal Medicine, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Cancer Rep (Hoboken). 2022 Aug;5(8):e1463. doi: 10.1002/cnr2.1463. Epub 2021 Jun 5.
Prostate cancer is the most prevalent cancer in men. However, leptomeningeal involvement by prostate carcinoma is a rare event.
Here, we report a 69-year-old patient with castration-resistant metastatic prostate cancer who presented with headache and ataxia. Brain MRI revealed a huge invasive interaxial mass at right occipital lobe with diffuse thickening and enhancement of meninges, the arachnoid, and the pia mater, and he was diagnosed with leptomeningeal carcinomatosis. The patient received whole brain radiotherapy.
Despite the fact that brain and leptomeningeal metastases are not very common in patients with prostate cancer, signs and symptoms of nervous system disorders should be assessed carefully, and consideration of such unusual metastases must be considered.
前列腺癌是男性最常见的癌症。然而，前列腺癌脑膜转移是一种罕见的事件。
这里，我们报告了一例 69 岁去势抵抗性转移性前列腺癌患者，表现为头痛和共济失调。脑部 MRI 显示右侧枕叶有巨大的侵袭性颅内肿块，脑膜、蛛网膜和软脑膜弥漫性增厚和强化，诊断为脑膜癌病。患者接受了全脑放疗。
尽管脑和脑膜转移在前列腺癌患者中并不常见，但应仔细评估神经系统障碍的迹象和症状，必须考虑到这种不常见的转移。
