Department of Oncology, Ygia Polyclinic, Limassol, Cyprus.
Clin Exp Metastasis. 2010;27(1):19-23. doi: 10.1007/s10585-009-9298-z. Epub 2009 Nov 11.
Leptomeningeal metastases from solid tumors are relatively uncommon events with dismal prognosis. They can be seen mainly in patients with breast and lung cancer, and malignant melanoma, but have also been described in a variety of other tumor types. Leptomeningeal carcinomatosis from prostate cancer is an extremely rare complication, but as patients' survival is prolonged due to more effective treatments, it is expected that more patients will present with leptomeningeal involvement in advanced stages of the disease. In these cases high levels of prostate-specific antigen can be found in the cerebrospinal fluid. This comprehensive review presents the recent findings from the literature.
脑脊髓转移瘤来自实体瘤，是一种预后极差的罕见事件。脑脊髓转移瘤主要发生在乳腺癌、肺癌和恶性黑色素瘤患者中，但也存在于多种其他肿瘤类型中。前列腺癌脑脊髓转移是一种极其罕见的并发症，但由于更有效的治疗方法，患者的生存时间延长，预计在疾病的晚期会有更多患者出现脑脊髓转移。在这些情况下，脑脊液中可检测到高浓度的前列腺特异性抗原。本文对文献中的最新研究结果进行了综述。
