前列腺癌软脑膜转移：一例报告并文献复习
Leptomeningeal Carcinomatosis of Prostate Cancer: A Case Report and Review of the Literature.
作者信息
Neeman Elad, Salamon Noriko, Rettig Matthew
机构信息
Department of Hematology and Oncology, Kaiser Permanente Northern California San Francisco, CA.
Department of Radiology, The David Geffen School of Medicine, UCLA Los Angeles, CA.
出版信息
Rev Urol. 2020;22(2):80-84.
Leptomeningeal carcinomatosis is a rare complication of prostate cancer. It is likely underdiagnosed as suggested by autopsy studies and is expected to become more prevalent with increasing survival of prostate cancer patients. Prostate cancer leptomeningeal carcinomatosis is associated with rapid functional decline and a median survival of approximately 1 month. Diagnosis is challenging because the clinical manifestations are varied, and no gold-standard diagnostic approach exists. Treatment of prostate cancer leptomeningeal carcinomatosis is not standardized and multiple approaches have been reported, mostly as case studies. Herein we report a case of a 73-year-old patient with metastatic castration-resistant prostate cancer who presented to our clinic with subacute cognitive decline, ataxia, and urinary incontinence, and was found to have leptomeningeal carcinomatosis.
软脑膜癌病是前列腺癌的一种罕见并发症。尸检研究表明，它可能未得到充分诊断，并且随着前列腺癌患者生存率的提高，预计其发病率会更高。前列腺癌软脑膜癌病与功能迅速衰退以及约1个月的中位生存期相关。诊断具有挑战性，因为临床表现多样，且不存在金标准诊断方法。前列腺癌软脑膜癌病的治疗尚无标准化方案，已报道的多种治疗方法大多为病例研究。在此，我们报告一例73岁转移性去势抵抗性前列腺癌患者，该患者因亚急性认知衰退、共济失调和尿失禁前来我院就诊，被诊断为软脑膜癌病。
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