Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Butenfeld 34, 22529, Hamburg, Germany.
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Int J Legal Med. 2022 Jan;136(1):193-202. doi: 10.1007/s00414-021-02618-8. Epub 2021 Jun 5.
The current pandemic with Severe acute respiratory syndrome-coronavirus-2 has been taking on new dynamics since the emergence of new variants last fall, some of them spreading more rapidly. Many countries currently find themselves in a race to ramp up vaccination strategies that have been initiated and a possible third wave of the pandemic from new variants, such as the Variant of Concern-202012/01 from the B.1.1.7 lineage. Until today, many investigations in death cases of Coronavirus-disease-19 have been conducted, revealing pulmonary damage to be the predominant feature of the disease. Thereby, different degrees of macroscopic and microscopic lung damage have been reported, most of them resembling an Acute Respiratory Distress Syndrome. Far more, systemic complications of the disease such as pulmonary embolisms have been described. However, neither morphologic nor virologic findings of patients dying of the new variants have yet been reported. Here, we report on a comprehensive analysis of radiologic, morphologic, and virologic findings in a fatal case of this variant.
自去年秋季出现新变种以来，当前由严重急性呼吸系统综合征冠状病毒 2 引起的大流行呈现出新的动态，其中一些变种传播得更快。许多国家目前都在竞相加大已启动的疫苗接种策略的力度，并防范新变种可能引发的第三次大流行，例如 B.1.1.7 谱系的 202012/01 关注变种。迄今为止，对冠状病毒病-19 的死亡病例进行了许多调查，结果表明肺部损伤是该疾病的主要特征。因此，报告了不同程度的宏观和微观肺损伤，其中大多数类似于急性呼吸窘迫综合征。更重要的是，还描述了该疾病的全身并发症，如肺栓塞。然而，尚未报告死于新变种的患者的形态学或病毒学发现。在这里，我们报告了对该变体导致的致命病例的放射学、形态学和病毒学发现的综合分析。
