Gao Bei-Bei, Ou Yu-Fei, Zhu Qin-Feng, Zhou Zhi-Ping, Deng Zhen-Tao, Li Meng, Zhao Qin-Shi
State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Yunnan, 650091, Kunming, People's Republic of China.
Nat Prod Bioprospect. 2021 Oct;11(5):557-564. doi: 10.1007/s13659-021-00315-y. Epub 2021 Jun 5.
Three new clerodane-type diterpene glycosides, (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1 → 4)-α-L-rhamnopyranosyl]cleroda-3,13(16),14-diene (1), (5R,6S,8R,9S,10R,13S)-6-O-[β-D-glucopyranosyl-(1 → 4)-α-L-rhamnopyranosyl]-2-ox-oneocleroda-3,13-dien-15-ol (2), (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1 → 4)-α-L-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol (3), together with two known compounds 4 and 5 were isolated from Dicranopteris pedata. The structures of these compounds were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 2 was determined by ECD calculations. In addition, compound 1 exhibited weak inhibitory activities against SMMC-7721, MCF-7 and SW480.
从芒萁中分离得到了三种新的克罗烷型二萜糖苷，即(5R,6S,8R,9S,10R)-6-O-[β-D-吡喃葡萄糖基-(1→4)-α-L-吡喃鼠李糖基]克罗达-3,13(16),14-二烯（1）、(5R,6S,8R,9S,10R,13S)-6-O-[β-D-吡喃葡萄糖基-(1→4)-α-L-吡喃鼠李糖基]-2-氧代新克罗达-3,13-二烯-15-醇（2）、(5R,6S,8R,9S,10R)-6-O-[β-D-吡喃葡萄糖基-(1→4)-α-L-吡喃鼠李糖基]-(13E)-2-氧代新克罗达-3,14-二烯-13-醇（3），以及两种已知化合物4和5。通过详细的光谱分析阐明了这些化合物的结构，并通过ECD计算确定了化合物2的绝对构型。此外，化合物1对SMMC-7721、MCF-7和SW480表现出微弱的抑制活性。
