Zakaria Zainul Amiruddin, Abdul Ghani Zuleen Delina Fasya, Raden Mohd Nor Raden Nur Suraya, Gopalan Hanan Kumar, Sulaiman Mohd Roslan, Abdullah Fatimah Corazon
Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A7/A, Seksyen 7, 40000 Shah Alam, Selangor, Malaysia.
Yakugaku Zasshi. 2006 Nov;126(11):1197-203. doi: 10.1248/yakushi.126.1197.
The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40 degrees C) to dryness, was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200 mg/kg and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all doses used, was found to exhibit significant (p<0.05) antinociceptive activity in a dose-dependent manner. However, the significant (p<0.05) anti-inflammatory activity observed occur in a dose-independent manner. As a conclusion, the chloroform extract of D. linearis possesses antinociceptive and anti-inflammatory activity and thus justify its traditional uses by the Malays to treat various ailments.
本研究旨在确定芒萁叶氯仿提取物在实验动物中的抗伤害感受和抗炎特性。使用腹部收缩、福尔马林和热板试验来测量抗伤害感受活性，而使用角叉菜胶诱导的爪肿胀来测量抗炎活性。将风干的叶子在氯仿中浸泡72小时，然后在真空（40摄氏度）下蒸发至干，得到的提取物溶解于二甲基亚砜中，制成20、100和200mg/kg的剂量，并在进行上述试验前30分钟皮下给药。在所使用的所有剂量下，提取物均以剂量依赖性方式表现出显著（p<0.05）的抗伤害感受活性。然而，观察到的显著（p<0.05）抗炎活性以非剂量依赖性方式出现。总之，芒萁氯仿提取物具有抗伤害感受和抗炎活性，因此证明了马来人将其用于治疗各种疾病的传统用途是合理的。
