Department of Obstetrics and Gynecology, Acıbadem Maslak Hospital, Istanbul, Turkey.
Private Clinic, Istanbul, Turkey.
J Gynecol Obstet Hum Reprod. 2021 Nov;50(9):102175. doi: 10.1016/j.jogoh.2021.102175. Epub 2021 Jun 2.
The aim of this study was to investigate the thiol/disulfide homeostasis in tubal ectopic pregnancies in terms of early diagnosis of the disease.
A prospective case-control study was carried out between June 2017-February 2018 in the Gynaecology Department of Umraniye Medical and Research Hospital.
A total of 42 women with ectopic pregnancy were compared with 44 healthy women who have intrauterine first trimester pregnancies. The thiol/disulfide homeostasis is evaluated with the spectrophotometric measurement method that was recently developed by Erel&Neselioglu.
Disulfide/native thiol and disulfide/total thiol ratios were increased (p = 0.018 and p = 0.023 respectively), while native thiol/total thiol ratios and native thiol levels were decreased in tubal ectopic pregnancy group according to control group (p = 0.023). Between control and tubal ectopic pregnancy groups no differences were measured in disulfide levels (p = 0.350). The area under curve for native thiol and total thiol were 0.937 and 0.927, respectively. The optimum cut off value for native thiol was 379.95 μmol/l with a sensitivity of 90% and specificity of 81%. The optimum cut off value for total thiol was 432.5 μmol/l had 92% sensitivity and 79% specificity.
In the study, whether intrauterine pregnancies resulted in miscarriage or delivery can be examined.
Increased disulfide/native thiol levels, disulfide/total-thiol ratio and decreased native/total thiol ratio were found to be significantly associated with the presence of tubal ectopic pregnancy which can be useful for the early diagnosis of the disease.
本研究旨在探讨输卵管妊娠患者的巯基/二硫键平衡与疾病的早期诊断。
本前瞻性病例对照研究于 2017 年 6 月至 2018 年 2 月在乌尔马尼亚医疗和研究医院妇科进行。
将 42 例异位妊娠患者与 44 例宫内早孕患者进行比较。巯基/二硫键平衡采用 Erel 和 Neselioglu 最近开发的分光光度测量法进行评估。
与对照组相比，输卵管妊娠组中二硫键/天然巯基和二硫键/总巯基的比值升高（p=0.018 和 p=0.023），而天然巯基/总巯基比值和天然巯基水平降低（p=0.023）。在对照组和输卵管妊娠组之间，二硫键水平无差异（p=0.350）。天然巯基和总巯基的曲线下面积分别为 0.937 和 0.927。天然巯基的最佳截断值为 379.95 μmol/l，灵敏度为 90%，特异性为 81%。总巯基的最佳截断值为 432.5 μmol/l，灵敏度为 92%，特异性为 79%。
在这项研究中，可以检查宫内妊娠是否导致流产或分娩。
与输卵管妊娠的存在显著相关的是，二硫键/天然巯基水平升高、二硫键/总巯基比值升高和天然巯基/总巯基比值降低，这可能有助于疾病的早期诊断。
