College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Int J Biol Macromol. 2021 Jul 31;183:2337-2353. doi: 10.1016/j.ijbiomac.2021.05.213. Epub 2021 Jun 6.
Angelica sinensis polysaccharide (ASP) is one of the main active components of Angelica sinensis (AS) that is widely used in traditional Chinese medicine. ASP is water-soluble polysaccharides, and it is mainly composed of glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl) and galacturonic acid (GalUA). The extraction methods of ASP include hot water extraction and ultrasonic wave extraction, and different extraction methods can affect the yield of ASP. ASP has a variety of pharmacological activities, including hematopoietic activity, promoting immunity, antitumor, anti-inflammatory, antioxidant, anti-aging, anti-virus, liver protection, and so on. As a kind of natural polysaccharide, ASP has potential application as drug carriers. This review provides a comprehensive summary of the latest extraction and purification methods of ASP, the strategies used for monosaccharide compositional analysis plus polysaccharide structural characterization, pharmacological activities and drug carrier applications, and it can provide a basis for further study on ASP.
当归多糖（ASP）是当归（AS）中主要的活性成分之一，广泛应用于中药。ASP 是水溶性多糖，主要由葡萄糖（Glc）、半乳糖（Gal）、阿拉伯糖（Ara）、鼠李糖（Rha）、岩藻糖（Fuc）、木糖（Xyl）和半乳糖醛酸（GalUA）组成。ASP 的提取方法包括热水提取和超声波提取，不同的提取方法会影响 ASP 的产率。ASP 具有多种药理活性，包括造血活性、促进免疫、抗肿瘤、抗炎、抗氧化、抗衰老、抗病毒、保肝等。作为一种天然多糖，ASP 具有作为药物载体的应用潜力。本文综述了 ASP 的最新提取和纯化方法、单糖组成分析加多糖结构表征的策略、药理活性和药物载体应用，为进一步研究 ASP 提供了依据。
