酗酒者在酗酒期间及戒酒过程中血液中转铁蛋白异构体的浓度差异。
Concentration differences in isoforms of transferrin in blood from alcoholics during abuse and abstinence.
作者信息
Petrén S, Vesterberg O
机构信息
Division of Medical Chemistry, National Institute of Occupational Health, Solna, Sweden.
出版信息
Clin Chim Acta. 1988 Jul 15;175(2):183-7. doi: 10.1016/0009-8981(88)90008-3.
At least five different forms of iron-saturated transferrin (Tf) from blood plasma can be separated by isoelectric focusing. These transferrin forms differ in the carbohydrate parts, especially the amount of sialic acid. The increased relative concentration of the form with isoelectric point 5.7 (Tf5.7) has been shown to be a good indicator for liver effects caused by alcohol abuse. However, in alcoholics during abstinence the newly formed transferrin has a higher sialic acid content than most of the transferrin already present in the blood. This indicates that the elevated concentration of Tf5.7 with a low sialic acid content, found in alcoholics is not due to a defect at sialylation, but most probably caused by an impaired uptake of sialic acid-deficient transferrin by the hepatocytes due to membrane dysfunction.
通过等电聚焦可分离出血浆中至少五种不同形式的铁饱和转铁蛋白（Tf）。这些转铁蛋白形式在碳水化合物部分存在差异，尤其是唾液酸的含量。已证明等电点为5.7的转铁蛋白形式（Tf5.7）相对浓度增加是酒精滥用所致肝脏效应的良好指标。然而，在戒酒期间的酗酒者中，新形成的转铁蛋白比血液中已存在的大多数转铁蛋白具有更高的唾液酸含量。这表明，在酗酒者中发现的低唾液酸含量的Tf5.7浓度升高并非由于唾液酸化缺陷，而很可能是由于膜功能障碍导致肝细胞对缺乏唾液酸的转铁蛋白摄取受损所致。
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