Ben David Noa, Mafi Mahsa, Nyska Abraham, Gross Adi, Greiner Andreas, Mizrahi Boaz
Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
Faculty of Biology, Chemistry and Earth Sciences, Bayreuth Center for Colloids and Interfaces, University of Bayreuth, Bayreuth 95440, Germany.
ACS Omega. 2021 May 20;6(21):13647-13653. doi: 10.1021/acsomega.1c00790. eCollection 2021 Jun 1.
Open wound dressings should provide a moist environment, protect the wound from bacterial contamination, and shield it from further damage. These requirements, however, are hard to accomplish since such wounds are colonized by pathogenic bacteria, including resistant species such as methicillin-resistant (MRSA). A new approach for treating open wounds that is based on sticky and dissolvable polyvinyl alcohol (PVA) microparticles containing live () is described. Microparticles, fabricated by the spray-drying technique, were administered directly to an open wound while continuously produced and secreted antimicrobial molecules. in PVA microparticles demonstrated remarkable antibacterial activity against MRSA and . In in vivo experiments, both and empty PVA microparticles were effective in decreasing healing time; however, microparticles were more effective during the first week. There was no evidence of skin irritation, infection, or other adverse effects during the 15 day postoperative observation period. This concept of combining live secreting bacteria within a supportive delivery system shows great promise as a therapeutic agent for open wounds and other infectious skin disorders.
开放性伤口敷料应提供一个湿润的环境，保护伤口免受细菌污染，并防止其受到进一步损伤。然而，由于此类伤口会被包括耐甲氧西林金黄色葡萄球菌（MRSA）等耐药菌在内的病原菌定植，这些要求很难实现。本文描述了一种基于含有活的（此处原文有缺失内容）的粘性且可溶解的聚乙烯醇（PVA）微粒治疗开放性伤口的新方法。通过喷雾干燥技术制备的微粒被直接应用于开放性伤口，同时（此处原文有缺失内容）持续产生并分泌抗菌分子。PVA微粒中的（此处原文有缺失内容）对MRSA和（此处原文有缺失内容）显示出显著的抗菌活性。在体内实验中，含有（此处原文有缺失内容）的微粒和空PVA微粒在缩短愈合时间方面均有效；然而，含有（此处原文有缺失内容）的微粒在第一周更为有效。在术后15天的观察期内，没有皮肤刺激、感染或其他不良反应的证据。这种在支持性递送系统中结合活的分泌细菌的概念，作为开放性伤口和其他感染性皮肤病的治疗剂显示出巨大的前景。
