State Key Laboratory for Managing Biotic and Chemical Treats to the Quality and Safety of Agro-products, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
State Key Laboratory for Managing Biotic and Chemical Treats to the Quality and Safety of Agro-products, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Virulence. 2021 Dec;12(1):1550-1562. doi: 10.1080/21505594.2021.1933370.
Septins, a conserved family of GTP-binding proteins, are widely recognized as an essential cytoskeletal component, playing important roles in a variety of biological processes, including division, polarity, and membrane remodeling, in different eukaryotes. Although the roles played by septins were identified in the model organism , their importance in other fungi, especially pathogenic fungi, have recently been determined. In this review, we summarize the functions of septins in pathogenic fungi in the cell cycle, autophagy, endocytosis and invasion host-microbe interactions that were reported in the last two years in the field of septin cell biology. These new discoveries may be expanded to investigate the functions of septin proteins in fungal pathogenesis and may be of wide interest to the readers of Microbiology and Molecular Pathology.
septins 是一类广泛存在于真核生物中的 GTP 结合蛋白家族，作为细胞骨架的重要组成部分，在有丝分裂、极性、膜重塑等多种生物学过程中发挥着重要作用。尽管 septins 的功能已在模式生物中得到鉴定，但近年来发现其在其他真菌，特别是病原真菌中的重要性。在这篇综述中，我们总结了 septin 在病原真菌细胞生物学领域中，过去两年报道的细胞周期、自噬、内吞和入侵宿主-微生物相互作用中的功能。这些新发现可能会扩展到研究 septin 蛋白在真菌发病机制中的功能，并且可能会引起微生物学和分子病理学读者的广泛兴趣。
