过硫化作用是自噬硫化信号转导的机制。
Persulfidation is the mechanism underlying sulfide-signaling of autophagy.
机构信息
Instituto de Bioquímica Vegetal y Fotosíntesis, CSIC-Universidad de Sevilla, Sevilla, Spain.
出版信息
Autophagy. 2022 Mar;18(3):695-697. doi: 10.1080/15548627.2021.1936357. Epub 2021 Jun 7.
Abstract
In this commentary, we highlight the findings described in a recent paper regarding the mechanism of HS regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.
摘要
在这篇评论中，我们强调了最近一篇论文中描述的关于哺乳动物细胞中 HS 调节大自噬/自噬的机制的研究结果，并讨论了与植物细胞的相似/差异之处。主要结果是，半胱氨酸残基的巯基的翻译后修饰形成过硫化物是一种保守的分子机制。
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本文引用的文献
1
Persulfidation of ATG18a regulates autophagy under ER stress in .PER 化的 ATG18a 在 ER 应激下调控自噬。
Proc Natl Acad Sci U S A. 2021 May 18;118(20). doi: 10.1073/pnas.2023604118.
2
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.硫化氢诱导 GAPDH 巯基化破坏 CCAR2-SIRT1 相互作用以启动自噬。
Autophagy. 2021 Nov;17(11):3511-3529. doi: 10.1080/15548627.2021.1876342. Epub 2021 Jan 30.
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The coordination of guard-cell autonomous ABA synthesis and DES1 function regulates plant water deficit responses.保卫细胞自主ABA合成与DES1功能的协调调节植物水分亏缺反应。
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Abscisic Acid-Triggered Persulfidation of the Cys Protease ATG4 Mediates Regulation of Autophagy by Sulfide.脱落酸触发半胱氨酸蛋白酶 ATG4 的过硫化作用介导硫化物对自噬的调控。
Plant Cell. 2020 Dec;32(12):3902-3920. doi: 10.1105/tpc.20.00766. Epub 2020 Oct 9.
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Hydrogen Sulfide: From a Toxic Molecule to a Key Molecule of Cell Life.硫化氢：从有毒分子到细胞生命的关键分子
Antioxidants (Basel). 2020 Jul 15;9(7):621. doi: 10.3390/antiox9070621.
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