Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea; email:
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
Annu Rev Chem Biomol Eng. 2021 Jun 7;12:359-391. doi: 10.1146/annurev-chembioeng-101420-024336.
High-performance wearable and implantable devices capable of recording physiological signals and delivering appropriate therapeutics in real time are playing a pivotal role in revolutionizing personalized healthcare. However, the mechanical and biochemical mismatches between rigid, inorganic devices and soft, organic human tissues cause significant trouble, including skin irritation, tissue damage, compromised signal-to-noise ratios, and limited service time. As a result, profuse research efforts have been devoted to overcoming these issues by using flexible and stretchable device designs and soft materials. Here, we summarize recent representative research and technological advances for soft bioelectronics, including conformable and stretchable device designs, various types of soft electronic materials, and surface coating and treatment methods. We also highlight applications of these strategies to emerging soft wearable and implantable devices. We conclude with some current limitations and offer future prospects of this booming field.
高性能可穿戴和可植入设备能够实时记录生理信号并提供相应的治疗，在推动个性化医疗方面发挥着关键作用。然而，刚性无机设备与柔软有机人体组织之间的机械和生化不匹配会导致严重问题，包括皮肤刺激、组织损伤、信噪比降低和有限的使用时间。因此，人们致力于通过使用灵活可拉伸的设备设计和柔软材料来克服这些问题。在这里，我们总结了最近在软电子领域的代表性研究和技术进展，包括顺应性和可拉伸设备设计、各种类型的软电子材料以及表面涂层和处理方法。我们还强调了这些策略在新兴软可穿戴和可植入设备中的应用。最后，我们总结了当前的一些局限性，并对这一蓬勃发展的领域的未来前景进行了展望。
