College of Sport Science, Chung-Ang University, Republic of Korea.
Department of Surgery, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Republic of Korea.
Exp Gerontol. 2021 Sep;152:111435. doi: 10.1016/j.exger.2021.111435. Epub 2021 Jun 18.
Physical activity prevents cancer and improves cancer outcomes. Insulin-like growth factor (IGF) signaling plays a significant role in cancer development and progression. However, there are heterogeneous results regarding physical activity and its effect on the IGF system. This study meta-analyzed the results of randomized clinical trials which evaluated the effects of physical exercise on the changes of physiologic markers to identify the role of physical exercise in modulating the IGF system in women with breast cancer.
PubMed, Embase, CENTRAL, and SPORTDiscus were systematically searched until October 2020. Eligibility criteria included randomized controlled trials that evaluated the effects of physical exercise on the insulin-like growth factor system among women with breast cancer.
Twelve randomized controlled studies involving 736 participants were analyzed. Physical exercise significantly reduced levels of serum insulin (MD -1.24 μIU/mL, 95% CI -2.12 to -0.36, p = 0.006), IGF-II (MD -54.21 ng/mL, 95% CI -61.41 to -47.00, p < 0.00001), IGFBP-1 (MD -2.90 ng/mL, 95% CI -3.91 to -1.90, p < 0.00001), and HOMA score (MD -0.47, 95% CI -0.87 to -0.06, p = 0.02). In addition, serum glucose (MD -0.71 mg/dL, 95% CI -2.57 to 1.15; p = 0.45) and IGF-I levels (MD -5.23 ng/mL, 95% CI -13.00 to 2.53; p = 0.19) were decreased after physical exercise although they did not show a statistical significance.
Physical exercise had a positive effect on the IGF system in women with breast cancer.
身体活动可预防癌症并改善癌症结局。胰岛素样生长因子（IGF）信号在癌症的发生和发展中起着重要作用。然而，关于身体活动及其对 IGF 系统的影响，研究结果存在差异。本研究通过荟萃分析评估身体运动对生理标志物变化影响的随机临床试验结果，以确定身体运动在调节乳腺癌女性 IGF 系统中的作用。
系统检索了 PubMed、Embase、CENTRAL 和 SPORTDiscus 数据库，检索时间截至 2020 年 10 月。纳入标准为评估身体运动对乳腺癌女性 IGF 系统影响的随机对照试验。
共分析了 12 项包含 736 名参与者的随机对照研究。身体运动可显著降低血清胰岛素水平（MD -1.24 μIU/mL，95% CI -2.12 至 -0.36，p = 0.006）、IGF-II 水平（MD -54.21 ng/mL，95% CI -61.41 至 -47.00，p < 0.00001）、IGFBP-1 水平（MD -2.90 ng/mL，95% CI -3.91 至 -1.90，p < 0.00001）和 HOMA 评分（MD -0.47，95% CI -0.87 至 -0.06，p = 0.02）。此外，虽然血清葡萄糖水平（MD -0.71 mg/dL，95% CI -2.57 至 1.15；p = 0.45）和 IGF-I 水平（MD -5.23 ng/mL，95% CI -13.00 至 2.53；p = 0.19）也有所降低，但无统计学意义。
身体运动对乳腺癌女性的 IGF 系统有积极影响。
